| Project/Area Number |
24500787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
HANAI Yoshiteru 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (50360730)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIZATO Hideo 名古屋工業大学, 大学院工学研究科, 准教授
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| Research Collaborator |
小畠 一輝 名古屋工業大学, 大学院工学研究科, 未来材料創成工学専攻
林 敦也 名古屋工業大学, 大学院工学研究科, 未来材料創成工学専攻
高木 裕士 名古屋工業大学, 生命物質工学科
早田 陽紀 名古屋工業大学, 生命物質工学科
鍋野 辰悟 名古屋工業大学, 生命物質工学科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | GH / IGF-1 / GH受容体 / IGF-1受容体 / 筋肥大 / 骨格筋 / 骨格筋肥大 |
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| Outline of Final Research Achievements |
In the present study, we investigated the expression levels of GH receptor and IGF-1 receptor in rat skeletal muscles, to clarify the regulation mechanisms of these receptor expressions. The expression levels of these receptors differ between muscles, and expression pattern of these two receptors among muscles also not consistent. In the muscle hypertrophy models, at the onset of hypertrophic response (<4days), only GH receptor mRNA was down regulated. An independent regulatory mechanism of these two receptors was suggested.
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