| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
This study was investigated to clarify the effects of icing and/or heat stress on the regeneration of injured rat soleus muscle by bupivacaine injection (BPVC).
Icing immediately after muscle injury delayed the timing of the decrease in the injury-related increase in the expression of transforming growth factor-β and accelerated the injury-related collagen deposition. Intermittent heat stress during the regeneration after injury enhanced the expression of CD68 and the number of Pax7-positive satellite cells at 3 or 7 days after injury, and inhibited the injury-related collagen deposition. Further, icing and intermittent heat stress after icing tended to retard the disappearance of embryonic and neonatal myosin heavy chain isoforms. These results strongly suggest that heat stress may be a beneficial treatment for injured skeletal muscle.
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