Effect of exercise training on sarcopenia: focused on fiber number

• Project/Area Number: 24500796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Tohoku Institute of Technology
• Principal Investigator: MASATAKA Suwa 東北工業大学, 公私立大学の部局等, 准教授 (50464392)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: サルコペニア / 筋線維数 / 老化 / 運動 / 骨格筋線維 / 骨格筋 / 加齢 / SIRT1

Outline of Final Research Achievements

The purpose of this research was to investigate the effect of exercise training or resveratrol treatment on age-related muscle fiber loss in mice. The research demonstrated that mice aged 24 months showed significant decrease in muscle fiber number of plantaris muscle in comparison to the mice aged 3 months. Wheel running training during 3 to 24 months age significantly attenuated such decrease. On the other hand, functional overload by tenotomy of gastrocnemius tendon or resveratrol treatment did not induce such phenomenon. The results imply that long-term endurance training would attenuate the age-related fiber loss in fast-twitch muscle.

Research Products

• [Journal Article] The Potential Role of Sirtuins Regarding the Effects of Exercise on Aging- Related Diseases (2013)
  • Author(s): Suwa M, Sakuma K.
  • Journal Title: Current Aging Science Volume: 6 Issue: 2 Pages: 178-188
  • DOI: 10.2174/18746098112059990035
  • Peer Reviewed
• [Presentation] 運動が加齢に伴う筋線維数の 減少を抑制する可能性 (2015)
  • Author(s): 諏訪雅貴
  • Organizer: P&PタイプA研究チーム、リサーチコアチーム共同による第6回公開講演会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2015-02-07
  • Invited
• [Book] Basic Biology and Current Understanding of Skeletal Muscle, Chapter 8, AMPK: molecular mechanisms of metabolic adaptations in skeletal muscle. (2013)
  • Author(s): Masataka Suwa
  • Total Pages: 45
  • Publisher: Nova Science Publishers Inc.
• [Book] AMPK: molecular mechanisms of metabolic adaptations in skeletal muscle. In, Basic Biology and Current Understanding of Skeletal Muscle (2013)
  • Author(s): Masataka Suwa
  • Publisher: Nova Science Publishers, NY