Effects of exercise training on novel tissue remodeling factor dermatopontin in white adipose tissue
| Project/Area Number |
24500798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Hideki 杏林大学, 医学部, 教授 (00133819)
KIZAKI Takako 杏林大学, 医学部, 教授 (00322446)
OGASAWARA Junetsu 杏林大学, 医学部, 助教 (20415110)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪組織 / 運動トレーニング / リモデリング / 細胞外マトリックス / デルマトポンチン / 組織性メタロプロテアーゼ阻害因子1 |
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| Outline of Final Research Achievements |
Recently, several studies have shown that white adipose tissue (WAT) fibrosis is enhanced in obese subjects. In the present study, we examined effects of exercise training (TR) on high fat diet (HFD)-induced expression changes of extracellular matrix (ECM) factors, such as dermatopontin (Dpt), in WAT, and attempted identification of roles of Dpt in WAT. The mRNA levels of Dpt, TGF-β, and TIMP1 in WAT of HFD-induced obese mice were significantly higher than those in WAT of control mice, and TR significantly attenuated the expression of these genes. The production of TIMP1 in 3T3-L1 cells were upregulated by treatment with TGF-β although Dpt did not affect. Moreover, treatment of 3T3-L1 cells with TIMP1 resulted in attenuation of insulin-induced glucose uptake. These results suggest that TR attenuates HFD-induced increases in ECM factors in WAT. Moreover, TR may improve insulin sensitivity by inhibiting accumulation of ECM which is associate with reduction of glucose uptake in WAT.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBα.2014
Author(s)
Sato S, Sakurai T, Ogasawara J, Shirato K, Ishibashi Y, Oh-ishi S, Imaizumi K, Haga S, Hitomi Y, Izawa T, Ohira Y, Ohno H & Kizaki T
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Journal Title
The Scientific World Journal
Volume: 2014
Pages: 685854-685854
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.2014
Author(s)
Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
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Journal Title
J Immunol.
Volume: 192
Issue: 1
Pages: 407-417
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells.2013
Author(s)
Sakurai T, Kitadate K, Nishioka H, Fujii H, Ogasawara J, Kizaki T, Sato S, Fujiwara T, Akagawa K, Izawa T, Ohno H.
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Journal Title
Br J Nutr.
Volume: 110
Issue: 9
Pages: 1549-1558
DOI
Related Report
Peer Reviewed
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[Journal Article] The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue.2013
Author(s)
Sakurai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Takahashi M, Kobayashi O, Oh-Ishi S, Nagasawa J, Takahashi K, Ishida H, Izawa T, Ohno H.
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Journal Title
Int J Endocrinol.
Volume: Article ID801743
Pages: 1-28
DOI
Related Report
Peer Reviewed
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[Presentation] ETAS, an enzyme-treated asparagus extract, has the ability to enhance both the differentaion and the neurite outgrowth in PC12 cells.2014
Author(s)
Ogsawara J, Takanari J, Sakurai T, Shirato K, Ishibashi Y, Nagasawa J, Izawa T, Ohno H & Kizaki T
Organizer
The 22nd International Congress on Nutrition and Integrative Medicine
Place of Presentation
Hotel Royton Sapporo（Sapporo, Hokkaido）
Year and Date
2014-07-26 – 2014-07-27
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