Combined effects of Microcurrent electrical neuromuscular stimulation and icing for injured skeletal muscles in mice.

• Project/Area Number: 24500802
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: FUJIYA HIROTO 聖マリアンナ医科大学, 医学部, 准教授 (50278008)
• Co-Investigator(Renkei-kenkyūsha): GOTO Katsumasa 豊橋創造大学大学院, 健康科学研究科, 教授 (70239961) ; OGURA Yuji 聖マリアンナ医科大学, 医学部, 講師 (90509952)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 微弱電流 / アイシング / 筋損傷 / 骨格筋 / 骨格筋損傷 / 筋衛生細胞 / 筋衛星細胞

Outline of Final Research Achievements

We evaluated the effect of Microcurrent electrical neuromuscular stimulation (MENS) combined with icing on the regeneration process in injured skeletal muscle in mice using immunohistochemical tequnique.
The cross sectional area of muscle fiber, number of Pax7-positive nuclei and Akt were increased by the combined effect of MENS and icing. In pathological investigation, infiltration of inflammatory cells was decreased by MENS with icing. These results suggested that a combination of MENS and icing for damaged skeletal muscles has an effect of acceleration muscle repair and regeneration. Since icing, which is widely performed in actual settings, has an effect of reducing pain and swelling, it is suggested that a combination of MENS and icing is epoch-making treatment method for skeletal muscle injuries.

Research Products

• [Journal Article] Microcurrent electrical neurouscular stimulation facilitates regeneration of injured skeletal muscle in mice (2015)
  • Author(s): Hiroto Fujiya, Yuji Ogura, Yoshitaka Ohno, Ayumi Goto, Ayane Nakamura, Kazuya Ohashi, Daiki Uematsu, Haruhito Aoki, Haruki Musha, Katsumasa Goto
  • Journal Title: Journal of Sports Science and Medicine Volume: 14 Pages: 297-303
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Icing at early stage depresses skeletal muscle regeneration. (2013)
  • Author(s): Tatsuto Ito, Hiroto Fujiya, Katsumasa Goto, Yuji Ogura, Mitsutoshi Kurosaka, Kanaka Yatabe, Satoshi Kisiro, Atsuhiro Yoshida, Hirotaka Yoshioka, Koh Terauchi, Moroe Beppu, Toshiya Funabashi, Tatsuo Akema, Haruki Musha
  • Journal Title: J. St. Marianna Univ. Volume: 4 (2 ) Pages: 61-67
  • NAID: 40019942526
  • Peer Reviewed
• [Journal Article] Microcurrent electrical nerve stimulation facilitates regrowth of mouse soleus muscle (2013)
  • Author(s): Ohno, Y., Fujiya, H., Goto, A., Nakamura, A., Nishiura, Y., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K
  • Journal Title: Intl. J. Med. Sci Volume: Vol.10, No.10 Issue: 10 Pages: 1286-1294
  • DOI: 10.7150/ijms.5985
  • NAID: 120005350264
  • Peer Reviewed
• [Presentation] Microcurrent electorical neuromuscular stimulation stimulates regenerative
  • Author(s): Fujiya H, Yuji Ogura, Yoshitaka Ohno, Ayumi Goto, Haruhito Aoki, Katsumasa Goto.
  • Organizer: 34th Annual Meeting International
  • Place of Presentation: Toyohashi, Japan
• [Presentation] 損傷骨格筋に対するアイシングの影響 -損傷後のアイシングの時期による検討-
  • Author(s): 伊藤龍登、藤谷博人、後藤勝正、小倉裕司、黒坂光寿、木城智、谷田部かなか、別府諸兄、船橋利也、明間立雄、武者春樹
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉
• [Remarks] 藤谷博人(フジヤヒロト)-聖マリアンナ医科大学 研究者情報
  • URL: http://gyoseki.marianna-u.ac.jp/smuhp/KgApp?kyoinId=ymisgkoyggy