Prevention of cognitive function of older people

• Project/Area Number: 24500803
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Ritsumeikan University
• Principal Investigator: Yuhaku Atsushi 立命館大学, スポーツ健康科学部, 准教授 (20399067)
• Co-Investigator(Kenkyū-buntansha): HAMAOKA Takafumi 東京医科大学, 医学部, 教授 (70266518) ; KURIHARA Toshiyuki 立命館大学, スポーツ健康科学部, 助教 (10454076)
• Co-Investigator(Renkei-kenkyūsha): FUJITA Satoshi 立命館大学, スポーツ健康科学部, 教授 (80451863) ; KUROSAWA Yuko 東京医科大学, 医学部, 助教 (90623108)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 加齢 / クレアチン / 認知機能 / 磁気共鳴分光法 (MRS) / 加齢研究 / 高齢者の認知機能改善 / 国際情報交換

Outline of Final Research Achievements

It is found that older people showed lower results for short-term memory and long-term memory, compared with younger subjects.

Research Products

• [Journal Article] 運動パフォーマンス向上のための機能性素材 (2016)
  • Author(s): 浜岡隆文、江崎和希、黒澤裕子
  • Journal Title: 食品と開発 Volume: 51 Pages: 8-10
  • Peer Reviewed
• [Journal Article] Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. (2012)
  • Author(s): Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M.
  • Journal Title: Nutrition Volume: 28 Pages: 1122-1126
  • Peer Reviewed
• [Journal Article] Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. (2012)
  • Author(s): Kurosawa Y, DeGrauw TJ, Lindquist DM, Blanco VM, Pyne-Geithman GJ, Daikoku T, Chambers JB, Benoit SC, Clark JF.
  • Journal Title: J Clin Invest Volume: 122 Pages: 2837-2846
  • Peer Reviewed
• [Presentation] Brain creatine and cognitive function in young and aged Japanese assessed by magnetic resonance spectroscopy (2015)
  • Author(s): Yuko Kurosawa, Atsushi Yuhaku, Toshiyuki Kurihara, Kohei Kido, Shiho Amagasa, Takafumi Hamaoka
  • Organizer: 2015 Creatine Conference
  • Place of Presentation: Laufen, Germany
  • Year and Date: 2015-04-24
• [Presentation] Combination of α-Glycerophosphocholine (α-GPC) intake and aerobic exercise improves cognitive functions in healthy older women.
  • Author(s): Yuhaku, A., Sato, K., Fujita, S., Hamaoka, T., and Iemitsu, M
  • Organizer: 18th annual Congress of the European College of Sports Science
  • Place of Presentation: Barcelona, Spain
• [Presentation] Magnetic resonance spectroscopy for brain.
  • Author(s): Kurosawa, Y., Kurihara, T., Yuhaku, A., and Hamaoka T.
  • Organizer: The 34th Guanidino Compounds Meeting
  • Place of Presentation: Tokyo, 全国町村会館
• [Presentation] "Combination of α-Glycerophosphocholine intake and aerobic exercise improves cognitive functions in healthy older women
  • Author(s): Atsushi Yuhaku, Koji Sato, Satoshi Fujita, Takeshi Okubo, Takafumi Hamaoka, Motoyuki Iemitsu
  • Organizer: EUROPEAN COLLEGE OF SPORT SCIENCE - 18th ECSS Congress
  • Place of Presentation: Barcelona, Spain.
• [Presentation] Cyclocreatine treatment of mice with the creatine transporter deficiency.
  • Author(s): Kurosawa Y, DeGrauw TJ, Lindquist DM, Blanco VM, Pyne-Geithman GJ, Daikoku T, Chambers JB, Benoit SC, Clark JF.
  • Organizer: The 35rd Guanidino Compounds Meeting
  • Place of Presentation: 市町村会館 (東京都)
  • Invited
• [Presentation] Creatine supplementation and skeletal muscle energy metabolism.
  • Author(s): Kurosawa Y, Hamaoka T.
  • Organizer: The 35rd Guanidino Compounds Meeting
  • Place of Presentation: 市町村会館 (東京都)
  • Invited
• [Book] Handbook of Modern Biophysics 4 “In-Vivo NIRS and Muscle Oxidative Metabolism” (2013)
  • Author(s): Takafumi Hamaoka
  • Total Pages: 17
  • Publisher: Springer Science