| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The purpose of this study is to investigate why fasting-related muscle atrophy is preferentially induced in fast-twitch muscles compared with slow-twitch muscles. We focused on differences of muscular activity level between fast-and slow-twitch muscles, and used three types of experimental models 1) compensatory overloading; 2)sciatic nerve denervation; 3) cast immobilization. Increasing of mechanical loading reduced the rate of muscle atrophy in fast-twitch plantaris muscle. On the other hand, decreasing of muscle activity by denervation and cast immobilization increased the rate of muscle atrophy in slow-twitch soleus muscle. These findings indicate preferential inducing of fasting-related muscle atrophy in fast muscles is partially related with the frequencies of nerve activity and mechanical loading.
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