The factor of preferential inducing of fasting-related atrophy in fast-twitch muscle
| Project/Area Number |
24500804
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Hiroshima Shudo University |
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Principal Investigator |
OGATA Tomonori 広島修道大学, 人間環境学部, 准教授 (30434343)
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| Co-Investigator(Renkei-kenkyūsha) |
OISHI Yasuharu 熊本大学, 教育学部 (10203704)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 筋萎縮 / 絶食 / 筋活動レベル / ギブス固定 / 除神経 / 筋活動 / mTOR |
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| Outline of Final Research Achievements |
The purpose of this study is to investigate why fasting-related muscle atrophy is preferentially induced in fast-twitch muscles compared with slow-twitch muscles. We focused on differences of muscular activity level between fast-and slow-twitch muscles, and used three types of experimental models 1) compensatory overloading; 2)sciatic nerve denervation; 3) cast immobilization. Increasing of mechanical loading reduced the rate of muscle atrophy in fast-twitch plantaris muscle. On the other hand, decreasing of muscle activity by denervation and cast immobilization increased the rate of muscle atrophy in slow-twitch soleus muscle. These findings indicate preferential inducing of fasting-related muscle atrophy in fast muscles is partially related with the frequencies of nerve activity and mechanical loading.
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Report
(4 results)
Research Products
(5 results)
