| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
The purpose of this study was to clarify whether chronic exercise after the spatial memory acquisition by aversive stimulation causes extinction of the spatial memory and changes of protein expression of brain derived neurotrophic factor (BDNF) and its receptor TrkB using rats induced hypothyroidism in the neonatal period. In normal rats, the retention of the spatial memory by Morris water maze (MWM) has been reduced after chronic running exercise, and BDNF in dorsal hippocampus has increased. In hypothyroid rat, the retention of the spatial memory by MWM has been reduced after chronic running exercise, and TrkB in the dorsal hippocampus has increased. It was suggested that chronic exercise after spatial memory acquisition by aversive stimulation would cause extinction of the spatial memory, and mechanisms of the extinction of the spatial memory in hypothyroid rats would be different from that in normal rats.
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