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Effects of Exercise on Neuromuscular Junction Morphology and Spinal Cord Motor Neurons Cells in Old Age

Research Project

Project/Area Number 24500806
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionShigakkan University Junior College

Principal Investigator

NISHIZAWA TOMIE  至学館大学短期大学部, その他部局等, 准教授 (30283980)

Co-Investigator(Kenkyū-buntansha) KASUGA Norikatsu  愛知教育大学, 教育学部, 教授 (60152659)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords老齢期 / 運動 / 神経筋接合部形態 / 脊髄運動神経細胞 / 筋線維 / 筋力 / 老化 / 神経筋接合部 / 筋機能 / 筋原性調節 / 筋活動量 / 加齢 / 筋機能特性
Outline of Final Research Achievements

There is a report that the morphological changes in the cell bodies of motor neurons in the spinal cord (MNsoma) and the muscle fibers they innervate are the factor of decreasing muscle strength in old age.
This study is an attempt to investigate how the exercise in old age influences the neuromuscular junction (NMJ) form and the muscle function.
The results suggest that the decrease of muscle strength in old age causes atrophy of muscle fibers and degeneration of the NMJ. However, exercising suppresses degenerative changes in the muscle fibers, the NMJ and loss in muscle strength. No significant change was observed in the MNsoma. The subsequent changes such as atrophy and degeneration in the MNsoma are inferred later on. In our understanding, the muscle fibers and NMJ forms have high plasticity and the MNsoma has high homeostasis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] 筋損傷にともなう神経筋接合部の変化2014

    • Author(s)
      春日規克、西沢富江、山下晋、辻本尚弥
    • Journal Title

      久留米大学健康・スポーツ科学センター紀要

      Volume: 21 Pages: 1-8

    • NAID

      120005448747

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥大を起こした筋線維の特性2013

    • Author(s)
      春日規克、石道峯典、幸篤武、西沢富江
    • Journal Title

      愛知教育大学研究報告 芸術・保健体育・家政・技術科学・創作編

      Volume: 63 Pages: 27-33

    • NAID

      120005261397

    • Related Report
      2013 Research-status Report
  • [Journal Article] 肥大を起こした筋線維の特性2013

    • Author(s)
      春日規克、石道峰典、幸篤武、西沢富江
    • Journal Title

      愛知教育大学研究報告

      Volume: 62 Pages: 27-33

    • NAID

      120005261397

    • Related Report
      2012 Research-status Report
  • [Presentation] 老齢ラットにおける脊髄運動神経細胞と神経筋接合部形態に関する研究2014

    • Author(s)
      西沢富江、春日規克
    • Organizer
      日本体力医学会
    • Place of Presentation
      長崎県
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Morphological Changes of Neuromuscular Junctions and Muscle Fibers Due to Inactivity in Rat Skeletal Muscle2013

    • Author(s)
      TOMIE NISHIZAWA,HIDEKI SUZUKI,NORIKATU KASUGA
    • Organizer
      34th Annual Meeting of International Society for Gravitational Physiology
    • Place of Presentation
      豊橋創造大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 再生筋線維の機能特性2013

    • Author(s)
      春日規克、石道峯典、幸篤武、西沢富江
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京 日本教育会館
    • Related Report
      2013 Research-status Report
  • [Presentation] 筋活動量がラット骨格筋における神経筋接合部形態および脊髄運動神経細胞に及ぼす 影響2013

    • Author(s)
      西沢富江、鈴木英樹、春日規克
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京 日本教育会館
    • Related Report
      2013 Research-status Report
  • [Presentation] 不活動がラット骨格筋神経筋接合部形態に及ぼす影響2012

    • Author(s)
      西沢富江、鈴木英樹、春日規克
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Morphological Changes of Neuromuscular Junctions Due to Inactivity in Rat Skeletal Muscle2012

    • Author(s)
      Nishizawa , T., SUZKI ,H. , YUKI . A. , NORIKATU ,K.,
    • Organizer
      17th ECSS Congress
    • Place of Presentation
      Bruges/BEL
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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