Studies on novel predicting factor for atherosclerosis in patients with diabetes

• Project/Area Number: 24500847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: SUZUKI Hiroaki 筑波大学, 医学医療系, 准教授 (40344890)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Kazuto 筑波大学, 医学医療系, 講師 (30455935) ; YATOH Shigeru 筑波大学, 医学医療系, 講師 (50451703) ; TAKAHASHI Akimitsu 筑波大学, 医学医療系, 准教授 (70344893)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 2型糖尿病 / 冠動脈疾患 / 内膜中膜複合体厚 / 冠動脈CT / バイオマーカー / 酸化LDL / 異所性脂肪蓄積 / 心肺運動負荷試験 / ２型糖尿病 / 頸動脈内膜中膜複合体厚 / リスクスコア

Outline of Final Research Achievements

Diabetic macroangiopathy is a common cause of mortality in patients with diabetes. Predicting diabetic macroangiopathy is important for personalized treatmen. We studied novel predicting factors for atherosclerosis in patinets with diabetes using coronary computed tomography angiography (CCTA) and carotid maximum intima-media thickness (max-IMT). We showed that max-IMT and MDA-LDL-related variables are useful predictors for coronary artery stenosis in patietnts with type 2 diabetes.

Research Products

• [Journal Article] Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes (2015)
  • Author(s): Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Yagyu H, Sone H, Shimano H.
  • Journal Title: Journal of diabetes research Volume: 印刷中 Pages: 507245-507245
  • DOI: 10.1155/2015/507245
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes (2014)
  • Author(s): Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 8 Pages: 799-815
  • DOI: 10.5551/jat.20487
  • NAID: 130004845472
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of Framingham Risk Score, UKPDS Risk Engine, JALS-ECC, and maximum carotid intima-media thickness for predicting coronary artery stenosis in asymptomatic patients with type 2 diabetes (2013)
  • Author(s): Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, et al.
  • Journal Title: Circulation Journal Volume: -
  • Peer Reviewed
• [Presentation] 2型糖尿病患者におけるMDA-LDLを用いた脂質指標の冠動脈狭窄病変予測能の検討 (2013)
  • Author(s): 藤原 和哉, 鈴木 浩明, 佐藤 明, 石津 智子, 平安座 依子, 児玉 暁, 高橋 昭光, 小林 和人, 矢藤 繁, 矢作 直也, 野牛 宏晃, 曽根 博仁, 島野 仁
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] Comparison of Framingham risk score, UKPDS risk engine, maximum-IMT, and LDL-C/HDL-C ratio for predicting coronary plaque in asymptomatic patients with type 2 diabetes. (2012)
  • Author(s): Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, et al.
  • Organizer: 48th EASD annual meeting
  • Place of Presentation: Berlin, Germany
• [Presentation] Comparison of Framingham Risk Score, UKPDS Risk Engine, JALS-ECC, and maximum-IMT for predicting coronary stenosis in asymptomatic patients with type 2 diabetes. (2012)
  • Author(s): Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, et al.
  • Organizer: 第44回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] フラミンガムリスクスコア、UKPDSリスクエンジン、max-IMT、LDL/HDL比による冠動脈病変予測能に関する検討． (2012)
  • Author(s): 藤原 和哉, 鈴木 浩明, 佐藤 明, 大崎 芳典, 尾本 美代子, 豊島 晶子, 平安座 依子, 児玉 暁, 斎藤 和美, 小林 和人, 矢藤 繁, 高橋 昭光, 山田 信博, 曽根 博仁, 島野 仁
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜