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Preventive effects and molecular mechanisms for metabolic abnormalities by a short-term intervention of caloric restriction and exercise

Research Project

Project/Area Number 24500849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionShinshu University

Principal Investigator

SAWASHITA Jinko  信州大学, 学術研究院医学系, 助教 (40359732)

Co-Investigator(Renkei-kenkyūsha) HIGUCHI Keiichi  信州大学, 学術研究院医学系, 教授 (20173156)
Research Collaborator LI Lin  信州大学, 医学系研究科, 大学院生
XU Zhe  信州大学, 医学系研究科, 大学院生
HUO Jia  信州大学, 医学系研究科, 大学院生
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords抗加齢 / 疾患モデルマウス / 軽度負荷運動 / 軽度カロリー制限 / 代謝改善 / 運動 / カロリー制限 / 脂質代謝 / 脂質代謝異常 / 疾患モデル動物
Outline of Final Research Achievements

This study is a basic research that analyzed beneficial effects of metabolic improvement and a disease control in mice, which are middle-aged and older having metabolic abnormalities or which have a systemic disease with age, by short-term individual high-intensity running exercise (HR) and mild caloric restriction (CR). The combination of HR and CR might improve more efficiently in basal metabolism than each treatment, and both HR and CR improved in pathologic progress in mice having the age-associated disease. These treatments may prevent the progression of inflammation and stress reaction, and it suggests that HR and/or CR have good effects to age-related metabolic decline.
These treatments suggest the possibility of contribution to health promotion to middle-aged and elder people.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Caloric restriction prevents the progression of murine AApoAII amyloidosis.2016

    • Author(s)
      J Sawashita, L Li, Y Liu, X Ding, M Yang, Z Xu, K Higuchi
    • Organizer
      The XVth International Symposium on Amyloidosis
    • Place of Presentation
      Uppsala (Sweden)
    • Year and Date
      2016-07-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 軽度な摂餌制限と個々の走力に応じた強度でのインターバル走行運動との短期併用は中高齢マウスの糖・脂質代謝を改善する2016

    • Author(s)
      澤下仁子、徐哲、霍佳、樋口京一
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動とカロリー制限はマウス老化(AApoAII)アミロイドーシスの発症を軽減する2015

    • Author(s)
      李琳、澤下仁子、劉穎業、丁欣、楊沐、徐哲、森政之、樋口京一
    • Organizer
      第38回日本基礎老化学会大会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2015-06-13 – 2015-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Exercise training plays a preventive role against mouse senile AApoAII amyloidosis.2015

    • Author(s)
      Lin Li, Jinko Sawashita, Masayuki Mori, Keiichi Higuchi
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動はAApoAIIアミロイド沈着を抑制する2014

    • Author(s)
      李琳、澤下仁子、劉穎業、丁欣、楊沐、徐哲、森政之、樋口京一
    • Organizer
      第2回日本アミロイドーシス研究会学術集会
    • Place of Presentation
      東京(KKRホテル東京)
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動はAApoAIIアミロイド沈着を抑制する2014

    • Author(s)
      李琳、澤下仁子、森政之、樋口京一
    • Organizer
      老化促進モデルマウス(SAM)研究協議会第29回研究発表会
    • Place of Presentation
      東京(東京都健康長寿医療センター)
    • Year and Date
      2014-07-05 – 2014-07-06
    • Related Report
      2014 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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