Study on the effect of insulin resisntance and chronic inflammation on sarcopenia
| Project/Area Number |
24500853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Nagoya University |
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Principal Investigator |
TERUHIKO Koike 名古屋大学, 名古屋大学総合保健体育科学センター, 教授 (90262906)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIDA Yoshiharu 名古屋大学, 総合保健体育科学センター, 教授 (10169295)
KUZUYA Masafumi 名古屋大学, 医学部, 教授 (10283441)
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| Co-Investigator(Renkei-kenkyūsha) |
SEI Kenbu 名古屋大学, 医学部, 准教授 (30378228)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | サルコペニア / EPA / インスリン抵抗性 / 慢性炎症 / 老化促進マウス |
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| Outline of Final Research Achievements |
The aim of the present study was to understand the mechanism of age-related muscle loss (sarcopenia) and to examine the effect of eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, on muscle. We used senescence accelerated prone mice (SAMP1), which are characterized by accelerated senile features, and senescence-resistant strain 1 mice (SAMR1) as control. Administration of EPA significantly increased muscle weight in SAMR1 but not in SAMP1. However, EPA had a tendency to increase muscle strength in SAMP1. Administration of EPA activated the signaling pathway associated with muscle protein synthesis in SAMR1, while it had no effect in SAMP1. The compensation muscle growth was not different between SAMP1 and SAMR1. Taken together, we conclude that administration of EPA is beneficial to prevent age-related loss of muscle mass and function.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Cathepsin K-mediated Notch 1 activation contributes to neovascularisation in response to hypoxia.2014
Author(s)
H. Jiang, XW. Cheng, GP. Shi, L. Hu, A Inoue, Y. Yamamura, H. Wu, K. Takeshita, X. Li, Z. Huang, H. Song, M. Asai, C. Hao, K. Unno, T. Koike, Y. Oshida, K. Okumura, T. Murohara, M. Kuzuya.
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Journal Title
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Peer Reviewed
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