Importance of life-stile for the predicitive risk of metabolic syndrome

• Project/Area Number: 24500854
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Osaka University
• Principal Investigator: YAMAUCHI-TAKIHARA Keiko 大阪大学, 保健センター, 教授 (70252640)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生活習慣病 / ライフスタイル / 喫煙 / 炎症 / 睡眠 / 禁煙指導

Outline of Final Research Achievements

Smoking and metabolic syndrome are major public health problems in modern society and are important risk factors of cardiovascular disease. Smokers presented high IL-6 and CRP than never-smokers. For female smokers, visceral fat area was significantly high when compared to never-smokers. Smoking habit was considered as one of the important risk factors of visceral fat accumulation and progression of subclinical atherosclerosis in women. Serum levels of soluble α-klotho (αKl) were significantly higher in smokers than in never-smokers. SαKl was positively correlated with IL-6 and was associated with IL-6-related environmental stresses. Smoking affected the anti-inflammatory network and metabolic disorders. Acceleration of aging induced by smoking habit can be explained from two aspects, inflammation and metabolic disorders, associated with sαKl and FGF-21. The present data could provide new insights into the prevention of aging and aging-related diseases induced by smoking habit.

Research Products

• [Journal Article] Gender differences in the relationship between blood pressure and body mass index during adolescence. (2015)
  • Author(s): N. Kawada, K. Nakanishi, T. Ohama, M. Nishida, K. Yamauchi-Takihara, T. Moriyama.
  • Journal Title: Obes Res Clin Pract Volume: 14 Issue: 2 Pages: 141-151
  • DOI: 10.1016/j.orcp.2014.07.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Temporal expression of growth factors triggered by epiregulin regulates inflammation development. (2015)
  • Author(s): Harada, M., Kamimura, D., Arima, Y., Kohsaka, H., Nakatsuji, Y., Nishida, M., Atsumi, T., Meng, J., Bando, H., Singh, R., Sabharwal, L., Jiang, J. J., Kumai, N., Miyasaka, N., Sakoda, S., Yamauchi-Takihara, K., Ogura, H., Hirano, T. & Murakami, M.
  • Journal Title: J Immunol Volume: 194 Issue: 3 Pages: 1039-1046
  • DOI: 10.4049/jimmunol.1400562
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Smoking associates visceral fat accumulation especially in women. (2014)
  • Author(s): K. Nakanishi, M. Nishida, T. Ohama, T. Moriyama, K. Yamauchi-Takihara.
  • Journal Title: Circ J Volume: 78 Pages: 1259-1263
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reference interval for the Apolipoprotein B-48 concentration in healthy Japanese individuals. (2014)
  • Author(s): D. Masuda, M. Nishida, T. Arai, H. Hanada, H. Yoshida, K.Yamauchi-Takihara, T. Moriyama, N. Tada, S. Yamashita.
  • Journal Title: J Atheroscler Thromb Volume: 21 Pages: 618-627
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The challenge of the “Estrogen Paradox” in pulmonary arterial hypertension. (2014)
  • Author(s): K. Yamauchi-Takihara.
  • Journal Title: Circ J Volume: 77 Pages: 1992-1993
  • Peer Reviewed
• [Journal Article] Is there a sex difference in Japanese patients with heart failure? (2014)
  • Author(s): S. Suna and K. Yamauchi-Takihara.
  • Journal Title: Circ J Volume: 78 Pages: 318-319
  • Peer Reviewed
• [Journal Article] 大阪大学における喫煙対策 (2014)
  • Author(s): 瀧原圭子
  • Journal Title: 臨床検査学教育 Volume: 6 Pages: 1-6
• [Journal Article] Disease-association analysis of an inflammation–related feedback loop. (2013)
  • Author(s): M. Murakami, D. Kamimura, M. Harada, H. Ogura, A. Okuyama, N. Kumai, R. Singh, J-J Jiang, Y. Okuyama, T. Atsumi, S. Shiraya, Y. Nakatsuji, M. Kinoshita, H. Kohsaka, M. Nishida, S. Sakoda, N. Miyasaka, K. Yamauchi-Takihara, T. Hirano
  • Journal Title: Cell Reports Volume: 3 Pages: 1-14
  • Peer Reviewed
• [Journal Article] Tocilizumab for the treatment of the patients with refractory Takayasu arteritis. (2013)
  • Author(s): Y. Nakaoka, K. Higuchi, Y. Arita, M. Otsuki, K.Yamamoto, T. Hashimoto, T. Yasui, K. Ikeoka, T. Ohtani, Y. Sakata, K. Yamauchi-Takihara, T. Tanaka, T. Kishimoto, I. Komuro.
  • Journal Title: Int Heart J Volume: 54 Pages: 405-411
  • Peer Reviewed
• [Journal Article] Is low testosterone concentration a risk factor for metabolic syndrome in healthy middle-aged men? (2013)
  • Author(s): Tsujimura A, Miyagawa Y, Takezawa K, Okuda H, Fukuhara S, Kiuchi H, Takao T, Yamamoto R, Nishida M, Yamauchi-Takihara K, Moriyama T, Nonomura N.
  • Journal Title: Urology Volume: 82 Pages: 814-819
  • Peer Reviewed
• [Journal Article] Disease-association analysis of an inflammation-related feedback loop. (2013)
  • Author(s): M. Murakami, D. Kamimura, (10), M. Kinoshita, H. Kohsaka, M. Nishida, S. Sakoda, N. Miyasaka, K. Yamauchi-Takihara, T. Hirano.
  • Journal Title: Cell Reports Volume: 3 Pages: 1-14
  • Peer Reviewed
• [Journal Article] Self-reported sleep duration and prediction of proteinuria: a retrospective cohort study. (2012)
  • Author(s): Yamamoto R, Nagasawa Y, Iwatani H, Shinzawa H, Obi Y, Teranishi J, Ishigami T, Yamauchi-Takihara K, Nishida M, Rakugi H, Isaka Y, Moriyama T.
  • Journal Title: Am J of Kidney Dis Volume: 59 Pages: 343-355
  • Peer Reviewed
• [Journal Article] Smoking promotes subclinical atherosclerosis in apparent healthy men. (2012)
  • Author(s): Sanada S, Nishida M, Ishii K, Moriyama T, Komuro I, Yamauchi-Takihara K.
  • Journal Title: Circ J Volume: 76 Pages: 2884-2891
  • Peer Reviewed
• [Journal Article] Endothelial Gab1 deletion accelerates Angiotensin II-dependent vascular inflammation and atherosclerosis in apolipoprotein E knockout mice. (2012)
  • Author(s): Higuchi K, Nakaoka Y, Shioyama W, Arita Y, Hashimoto T, Yasui T, Ikeoka K, Kuroda T, Nishida K, Fujio Y, Yamauchi-Takihara K, Shirai M, Mochizuki N, Komuro I.
  • Journal Title: Circ J Volume: 76 Pages: 2031-2040
  • Peer Reviewed
• [Journal Article] Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men. (2012)
  • Author(s): Tsujimura A, Yamamoto R, Okuda H, Yamamoto K, Fukuhara S, Yoshioka I, Kiuchi H, Takao T, Miyagawa Y, Nishida M, Yamauchi-Takihara K, Moriyama T, Nonomura N.
  • Journal Title: Endocr J Volume: 59 Pages: 809-815
  • Peer Reviewed
• [Presentation] 青年期における血圧と肥満度の関連性への性差の影響 (2014)
  • Author(s): 梅野有希、熊谷一代、川田典孝、中西香織、西田 誠、守山敏樹、瀧原圭子
  • Organizer: 第52回全国保健管理研究集会
  • Place of Presentation: 慶応大学
  • Year and Date: 2014-09-03 – 2014-09-04
• [Presentation] 学生健康教育としてのがん・緩和ケア・サイコオンコロジー講義の有用性と課題について (2014)
  • Author(s): 壁下康信、足立浩祥、谷向仁、竹中菜苗、石金直美、水田一郎、 工藤喬、瀧原圭子
  • Organizer: 第52回全国保健管理研究集会
  • Place of Presentation: 慶応大学
  • Year and Date: 2014-09-03 – 2014-09-04
• [Presentation] 麻疹、風疹等各種ワクチン接種対象者の年次推移とワクチンによる抗体獲得率 (2013)
  • Author(s): 村井教子 川村淳子 熊谷一代 藤田亜佐子 中西香織 大濱透 川田典孝 西田誠 守山敏樹 瀧原圭子
  • Organizer: 第51回全国大学保健管理研究集会
  • Place of Presentation: 岐阜
• [Presentation] 大阪大学教職員における喫煙についての調査～女性における喫煙の影響について (2013)
  • Author(s): 梅野有希，米田桃子，中西香織，川村淳子，村井教子，熊谷一代，大濱 透，川田典孝，西田 誠，守山敏樹，瀧原圭子
  • Organizer: 第51回全国大学保健管理研究集会
  • Place of Presentation: 岐阜
• [Presentation] 毛細血管拡張症が後の顕在化してきた肺高血圧症の一例 (2013)
  • Author(s): 正木 豪、大谷朋仁、中岡良和、坂田泰史、南都伸介、瀧原圭子、小室一成
  • Organizer: 第２回日本肺循環学会学術集会
  • Place of Presentation: 東京
• [Presentation] Smoking duration governs subclinical atherosclerotic progression stronger than duration of smoking cessation in apparent healthy men.n (2013)
  • Author(s): 真田昌爾、西田 誠、小室一成、瀧原圭子
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 大阪大学における学生喫煙率の推移と課題 (2012)
  • Author(s): 林ルミ、熊谷一代、村井教子、川村淳子、大濵 透, 真田昌爾、西田 誠、守山敏樹、 杉田義郎、瀧原圭子
  • Organizer: 第50回全国大学保健管理研究集会
  • Place of Presentation: 神戸
• [Presentation] 思春期におけるアレルギー疾患に関する実態調査 (2012)
  • Author(s): 木嶋晶子、室田浩之、熊谷一代、瀧原圭子、片山一朗
  • Organizer: 第50回全国大学保健管理研究集会
  • Place of Presentation: 神戸
• [Presentation] 心血管疾患における性差医療 (2012)
  • Author(s): 瀧原圭子
  • Organizer: 第60回心臓病学会
  • Place of Presentation: 金沢
  • Invited