Prevention of atrial thrombosis by food-derived bioactive components which act cardiovascular endothelial cells

• Project/Area Number: 24500857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: MAWATARI Kazuaki 徳島大学, ヘルスバイオサイエンス研究部, 講師 (40352372)
• Co-Investigator(Kenkyū-buntansha): SHIMOHATA Takaaki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (90609687)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 血管内皮細胞 / 心房血栓 / 一酸化窒素

Outline of Final Research Achievements

Left atrial (LA) thrombosis is an important cause of systemic embolization. The aim of the present study was to investigate how spontaneous model rats develop LA thrombi. Nitric oxide (NO) produced from cardiovascular endothelial cells plays an important protective role in blood flow, vascular tone, and platelet aggregation. No evidence of atrial fibrillation or hypercoagulability in the model rats regardless of age was found; however, the model rats demonstrated endothelial dysfunction and a decrease of NO production. In addition, endothelial NO synthase activity was significantly decreased in the LA and thoracic aorta endothelia of the model rats. However, L-arginine treatment significantly increased NO production and provided protection from the development of LA thrombi in the model rats. They present study results indicate that NO has an important role in the development of LA thrombus, and endothelial pathways could provide new targets of therapy to prevent LA thrombosis.

Research Products

• [Journal Article] Enhancement of Endothelial Function Inhibits Left Atrial Thrombi Development in an Animal Model of Spontaneous Left Atrial Thrombosis (2014)
  • Author(s): Kazuaki Mawatari, Emiko Yoshioka, Satomi Toda, Sonoko Yasui, Hiroko Furukawa, Takaaki Shimohata, Takamasa Ohnishi, Masaki Morishima, Nagakatsu Harada, Akira Takahashi, Hiroshi Sakaue, Yutaka Nakaya
  • Journal Title: Circulation Journal Volume: 78 Issue: 8 Pages: 1980-1988
  • DOI: 10.1253/circj.CJ-13-1398
  • NAID: 130004427936
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A novel peptide of endothelin family, 31 amino-acid length endothelin in patients with acute myocardial infarction (2014)
  • Author(s): Makiko Oka, Yasuharu Niwa, Kazuaki Mawatari, Yoshikazu Hiasa, Yutaka Nakaya
  • Journal Title: The Journal of Medical Investigation Volume: 61 Issue: 3.4 Pages: 298-305
  • DOI: 10.2152/jmi.61.298
  • NAID: 130004822735
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of a Model of Spontaneously-Running-Tokushima-Shikoku Rats with Left Atrial Thrombosis (2014)
  • Author(s): Takamasa Ohnishi, Fumiko Hisaoka, Masaki Morishima, Akira Takahashi, Nagakatsu Harada, Kazuaki Mawatari, Hidekazu Arai, Emiko Yoshioka, Satomi Toda, Izumi Keisuke, Yutaka Nakaya
  • Journal Title: Journal of Toxicologic Pathology Volume: 27 Issue: 1 Pages: 51-56
  • DOI: 10.1293/tox.2012-0032
  • NAID: 130003382469
  • ISSN: 0914-9198, 1881-915X
  • Peer Reviewed
• [Journal Article] Blueberry intervention improves vascular reactivity and lowers blood pressure in high fat, high cholesterol fed rats (2013)
  • Author(s): Ana Rodriguez-Mateos, Akari Ishisaka, Kazuaki Mawatari, Alberto Vidal-Diez, Jeremy Spencer, Junji Terao
  • Journal Title: British Journal of Nutrition Volume: 109 Issue: 10 Pages: 1746-1754
  • DOI: 10.1017/s0007114512003911
  • Peer Reviewed