| Project/Area Number |
24500859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Oita University |
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Principal Investigator |
GOTOH KORO 大分大学, 医学部, 助教 (10457624)
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| Co-Investigator(Kenkyū-buntansha) |
KAKUMA Tetsuya 大分大学, 医学部, 講師 (80343359)
MASAKI Takayuki 大分大学, 医学部, 助教 (00423715)
SEIKE Masataka 大分大学, 医学部, 助教 (40253794)
CHIBA Seiichi 大分大学, 医学部, 助教 (20457633)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 脾臓 / IL-10 / メタボリックシンドローム / 高脂肪食 / サイトカイン |
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| Outline of Final Research Achievements |
High-fat diet (HFD) feeding induces the reduction of IL-10 synthesis from spleen and this decrease promotes inflammation and ectopic fat deposit in multiple organs, disorder of glucose and lipid metabolism, and hypertension. Moreover, switching to a low-fat diet (LFD) restores IL-10 synthesis in spleen and improved multiple organs damage induced by HFD feeding. Clinically, LFD feeding is recommended to prevent the development of metabolic syndrome. However, IL-10 synthesis ability derived from spleen is important to utilize switching from HFD to LFD1 feeding. Thus, "splenic function" might be necessary to consider the treatment strategy to metabolic syndrome.
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