New function of fat-soluble compounds for improvement of life style diseases

• Project/Area Number: 24500863
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Minatogawa College (2014); Kobe University (2013); Kyoto Prefectural University of Medicine (2012)
• Principal Investigator: ADACHI Tetsuya 湊川短期大学, その他部局等, 教授 (60345014)
• Co-Investigator(Renkei-kenkyūsha): 松永 哲郎 鳴門教育大学, 講師 (10452286) ; 奥野 恭史 京都大学, 教授 (20283666)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: GPCR / 生活習慣病 / Gタンパク共役型受容体 / シグナル伝達 / エストロゲン / 受容体 / 代謝異常疾患

Outline of Final Research Achievements

We examined the expression and function of G-protein coupled receptor (GPCR) for fat-soluble compounds in circulation and skeletal muscle system. We discovered the expression of some fat-soluble ligand receptors in heart and skeletal muscle. GPR30 is the GPCR for estrogen. Estrogen induced the phosphorylation of ERK signal cascade in primary-cultured cardiomyocyte and skeletal muscle cell line. Moreover, estrogen via GPR30 induced the proliferation and the highly-expression of several transcription factors of these cells. These results suggest that new function of G-protein coupled receptor (GPCR) for fat-soluble compounds improves for life style diseases and metabolic syndrome.

Research Products

• [Journal Article] New physiological functions of fat-soluble compounds (2015)
  • Author(s): Adachi T
  • Journal Title: Proc Minatogawa Volume: 51 Pages: 55-60
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Androgen Receptor Silences Thioredoxin-interacting Protein and Competitively Inhibits Glucocorticoid Receptor-Mediated Apoptosis in Pancreatic β-Cells. (2015)
  • Author(s): Harada N, Katsuki T, Takahashi Y, Masuda T, Yoshinaga M, Adachi T, Izawa T, Kuwamura M, Nakano Y, Yamaji R, Inui H.
  • Journal Title: J Cell Biochem. Volume: 116 Issue: 6 Pages: 998-1006
  • DOI: 10.1002/jcb.25054
  • Peer Reviewed / Open Access
• [Journal Article] S-equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. (2014)
  • Author(s): Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, Yamaji R.
  • Journal Title: J Nutr Sci Vitaminol Volume: 60 Pages: 291-296
  • NAID: 130004695722
  • Peer Reviewed / Open Access
• [Journal Article] Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells. (2014)
  • Author(s): Matsunaga T, Li S, Adachi T, Joo E, Gu N, Yamazaki H, Yasuda K, Kondoh T, Tsuda K.
  • Journal Title: Biosci Biotechnol Biochem. Volume: 78 Issue: 5 Pages: 843-850
  • DOI: 10.1080/09168451.2014.905175
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells. (2014)
  • Author(s): Matsunaga T,Li S, Adachi T, Joo E, Gu N, Yamazaki H, Yasuda K, Kondoh T, Tsuda K.
  • Journal Title: Biosci Biotechnol Biochem Volume: 78 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Intrinsic left atrial histoanatomy as the basis for reentrant excitation causing atrial fibrillation/flutter in rats (2013)
  • Author(s): Matsuyama T, Tanaka H, Adachi T, Jiang Y, Ishibashi-Ueda H, Takamatsu T
  • Journal Title: Heart Rhythm Volume: 10 Issue: 9 Pages: 1342-1348
  • DOI: 10.1016/j.hrthm.2013.04.021
  • Peer Reviewed
• [Journal Article] γ-Tocotrienol attenuates TNF-α-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes. (2012)
  • Author(s): Matsunaga T, Shoji A, Gu N, Joo E, Li S, Adachi T, Yamazaki H, Yasuda K, Kondoh T, Tsuda K.
  • Journal Title: Mol Med Rep. Volume: 5 Issue: 4 Pages: 905-909
  • DOI: 10.3892/mmr.2012.770
  • Peer Reviewed
• [Presentation] 脂溶性物質の新しい生理機能 (2014)
  • Author(s): 足達哲也
  • Organizer: 日本技術士会生物工学部会研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18
  • Invited