| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Human skeletal muscle cells (Huskmcs) were cultured and pressurized to spuriously reproduce an intra-muscular pressure elevation during exercise. Investigations of mRNA expression in pressurized Huskmcs resulted in an increase in several secreted endocrine factors known as myokines, and protein levels in culture medium were also increased compared with non-pressurized cells. An administration of culture medium, collected by pressurized Huskmcs, to human adipocytes resulted in an increase in more than two times of up-regulation in cytokine release into culture medium. Huskmcs may play as a secretory organ during exercise and those released factors may have effect on adipocytes as a myokine.
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