Evaluating the severity and the development of lifestyle-related diseases visually and quantitatively on sonography
| Project/Area Number |
24500866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI Hiroaki 杏林大学, 医学部, 教授 (80291326)
WATANABE Takashi 杏林大学, 医学部, 教授 (00191768)
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| Research Collaborator |
MATSUSHIMA Satsuki 杏林大学, 医学部, 実験助手 (80231596)
MORI Hideaki 杏林大学, 医学部, 教授 (10239618)
URATA Tsuyoshi 杏林大学, 医学部付属病院, 検査技師
WATANABE Keiko 杏林大学, 医学部付属病院, 検査技師
FUJINO Aeka 杏林大学, 医学部付属病院, 検査技師
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生活習慣病 / 超音波 / 脂肪酸 / 脂肪 / 肝臓 / 脂肪組織 / 脂肪厚 / 脂肪酸組成 / 炎症 / サイトカイン |
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| Outline of Final Research Achievements |
This study was aimed to clarify whether the severity and the development of lifestyle-related diseases could be evaluated visually and quantitatively on sonography. (1) The alteration in serum fatty acids could be a marker of the severity. Abdominal visceral fat thickness measured on sonography was the most effective criterion. Furthermore, shear wave velocity in the abdominal adipose tissue or the liver, each measured with a new method of sonography, was significantly related to the severity. (2) Meanwhile, when measuring adipose tissue thickness around the heart on sonography, epicardial adipose tissue thickness was closely associated with the early impairment of left ventricular systolic function. Thus, it was suggested that the severity of lifestyle-related diseases and the development of their complications could be evaluated visually and quantitatively using sonography. Significant findings were obtained to establish a new clinical technique on lifestyle-related diseases.
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Report
(5 results)
Research Products
(3 results)
