| Project/Area Number |
24500876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
YAMADA Hisao 関西医科大学, 医学部, 教授 (00142373)
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| Co-Investigator(Renkei-kenkyūsha) |
KUREBAYASHI Shuji 静岡大学, 教育学部, 教授 (60402228)
MORI Tetsuji 鳥取大学, 医学部, 教授 (30285043)
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| Research Collaborator |
KOIKE Taro 関西医科大学, 医学部, 助教 (00735590)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経新生 / 海馬歯状回 / 昇降運動 / BrdU / 細胞更新 / マウス / 海馬 / ニューロン新生 / 運動負荷 / 傾斜トンネル / ランニングローター / 定量的評価 / 運動 / 遊具型トンネル |
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| Outline of Final Research Achievements |
Keeping in an enriched environment increases neurogenesis in the dentate gyrus of adult animals. We focused on upslope exercises and kept mice in three types of cages with slant tunnels for two weeks. During the period, the mice were allowed to behave voluntarily, and BrdU was ingested with drinking water (1mg/ml). The volume of water intake (i.e. BrdU intake) and the number of passage through the sensor in tunnel did not show apparent differences. In the specimens of hippocampal dentate gyrus, the BrdU-positive neuronal precursors were counted. The number of the 90-degree group (14.2) is significantly higher than the number of 0-degree group (9.6) and control group (9.5). Our findings demonstrate that voluntary upslope exercise is one of the components of enriched environments and sufficient for enhanced neurogenesis in the adult murine dentate gyrus.
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