| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In order to clarify that our hypothesis is that the decreasing physical activity in metabolic syndrome might be induced by macrophage differentiation, we investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged muscle using in vitro models of muscle injury. Although the chemotactic activity of M1 macrophages disappeared completely, M2 cells exhibited accelerated chemotactic activity toward damaged muscle cells. These results suggest that the metabolic syndrome-induced reduction of physical activity depend on the differentiation of M1 type of macrophages, which show a decrease in chemotaxis towards damaged myocytes.
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