The influence of macrophage differentiation on decreasing physical activity in metabolic syndrome
Project/Area Number |
24500878
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Kawasaki University of Medical Welfare |
Principal Investigator |
YANO HIROMI 川崎医療福祉大学, 医療技術学部, 准教授 (20248272)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | Taxiscan / M1マクロファージ / M2マクロファージ / 筋損傷モデル / C2C12細胞 / J774細胞 / MCP-1 / CCR2 / マクロファージ / 走化性 / 損傷骨格筋 / 細胞走化性測定装置 / J774 / C2C12 / F-actin / PI3K / LPS |
Outline of Final Research Achievements |
In order to clarify that our hypothesis is that the decreasing physical activity in metabolic syndrome might be induced by macrophage differentiation, we investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged muscle using in vitro models of muscle injury. Although the chemotactic activity of M1 macrophages disappeared completely, M2 cells exhibited accelerated chemotactic activity toward damaged muscle cells. These results suggest that the metabolic syndrome-induced reduction of physical activity depend on the differentiation of M1 type of macrophages, which show a decrease in chemotaxis towards damaged myocytes.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The suppression of tumor necrosis factor–alpha production in response to pathogen stimulation by strenuous exercise and the underlying mechanisms.2012
Author(s)
Yano, H., Uchida, M., Oyanagi, E., Kawanishi, N., Shiva, D., Kitamura, H.
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Journal Title
J. Physical Fitness Sports Med.
Volume: 1
Pages: 654-653
NAID
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[Presentation] Exhaustive exercise enhances immune response to flagellin via adrenaline-mediated up-regulation of TLR5.2013
Author(s)
Uchida, M., Oyanagi, E., Miyachi, M., Kremenik, M.J., Onodera, S., Yano, H.
Organizer
The 11th International Society of Exercise and Immunology (ISEI) Symposium
Place of Presentation
ニューキャスルタウンホール(オーストラリア)
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[Presentation] Relationship between macrophage differentiation and the chemotactic activity toward damaged muscle cells
Author(s)
Yano, H., Uchida, M., Oyanagi, E., Yamauchi, A., Kremenik, M.J.
Organizer
The 11th International Society of Exercise and Immunology (ISEI) Symposium
Place of Presentation
Newcastle Town Hall (Newcastle, Australia)
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