Establishment of the assessment of salt intake in hypertensive patients and general population.

• Project/Area Number: 24500884
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: National Hospital Organization, Kyushu Medical Center (Clinical Institute)
• Principal Investigator: TSUCHIHASHI Takuya 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, その他 (30163827)
• Co-Investigator(Renkei-kenkyūsha): IMAIZUMI Yuki 福岡県宗像市国保大島診療所
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 高血圧 / 食塩 / 生活習慣 / 質問票

Outline of Final Research Achievements

Measurement of 24-h urinary salt excretion is the most reliable method to assess salt intake of the hypertensive patietns. However, its use is restricted because of the requirement of the validation of 24-h urine collection. The assessment by using spot urine is simple and can be measured repeatedly. Combined assessment of urinary salt excretion and the salt content of the food consumued by the individuals is effective for the practical guidance of salt reduction in hypertensive patients as well as for the general population.

Research Products

• [Journal Article] Relationship between salt intake as estimated by a brief self-administered diet-history questionnaire (BDHQ) and 24-h urinary salt excretion in hypertensive patients. (2015)
  • Author(s): Sakata S, Tsuchihashi T, Oniki H, et al.
  • Journal Title: Hypertension Research Volume: 38 Issue: 8 Pages: 560-563
  • DOI: 10.1038/hr.2015.35
  • Peer Reviewed
• [Journal Article] Variability of urinary salt excretion estimated by spot urine in treated hypertensive patients. (2015)
  • Author(s): Arakawa K, Sakaki M, Sakata S, et al.
  • Journal Title: Clinical and Experimental Hypertension Volume: 37
  • Peer Reviewed
• [Journal Article] Long-term variability of urinary salt excretion and blood pressure in hypertensive patients (2014)
  • Author(s): Sakaki M, Tsuchihashi T, Arakawa K, et al.
  • Journal Title: Hypertension Research Volume: 39 Pages: 939-943
  • Peer Reviewed
• [Journal Article] Characteristics of the hypertensive patients with good and poor compliance to long-term salt restriction (2014)
  • Author(s): Sakaki M, Tsuchihashi T, Arakawa K.
  • Journal Title: Clinical and Experimental Hypertension Volume: 36 Pages: 92-96
  • Peer Reviewed
• [Journal Article] [Scientific statement] Report of the salt reduction committee of the Japanese Society of Hypertension (3) Assessment and application of salt intake in the management of hypertension (2013)
  • Author(s): Tsuchihashi T, Kai H, Kusaka M, et al.
  • Journal Title: Hypertension Research Volume: 36 Issue: 12 Pages: 1026
  • DOI: 10.1038/hr.2013.103
  • Peer Reviewed
• [Journal Article] High salt intake promotes a decline in renal function in hypertensive patients: a 10-year observational study. (2013)
  • Author(s): Ohta Y, Tsuchihashi T, Kiyohara K, Oniki H
  • Journal Title: Hypertension Research Volume: 36 Issue: 2 Pages: 172-176
  • DOI: 10.1038/hr.2012.155
  • Peer Reviewed
• [Journal Article] 高血圧患者における食塩摂取量の時代的推移と減塩指導効果 (2013)
  • Author(s): 鬼木秀幸、土橋卓也、榊美奈子、荒川仁香
  • Journal Title: 血圧 Volume: 20 Pages: 626-629
  • Peer Reviewed
• [Journal Article] 高血圧患者における簡易食事調査票『塩分チェックシート』の妥当性についての検討 (2013)
  • Author(s): 土橋卓也、増田香織、鬼木秀幸、榊美奈子、荒川仁香、亀田和花子、福井浩子
  • Journal Title: 血圧 Volume: 20 Pages: 1239-1243
  • Peer Reviewed
• [Journal Article] Validation of a self-monitoring device for estimating 24-hour urinary salt excretion (2013)
  • Author(s): Yasutake K, Sawano K, Shono N, Tsuchihashi T
  • Journal Title: Asia Pacific Journal of Clinical Nutrition Volume: 22 Pages: 25-31
  • Peer Reviewed
• [Journal Article] Influence of Salt Intake on Target Organ Damages in Treated Hypertensive Patients (2012)
  • Author(s): Ohta Y, Tsuchihashi T, Kiyohara K
  • Journal Title: Clinical and Experimental Hypertensoin Volume: 34 Issue: 5 Pages: 316-320
  • DOI: 10.3109/10641963.2011.618199
  • Peer Reviewed
• [Presentation] 高血圧管理における食塩摂取量の評価と応用 (2014)
  • Author(s): 土橋卓也
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-10-17 – 2014-10-19
  • Invited
• [Presentation] 高血圧外来患者における尿中食塩排泄量の変動性ー随時尿を用いた検討 (2014)
  • Author(s): 荒川仁香、榊美奈子、坂田智子、鬼木秀幸、冨永光裕、土橋卓也
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] The effect of 2-year intervention on blood pressure in the community of Japanese small island habitants (2014)
  • Author(s): Imaizumi Y, Eguchi K, Tsuchihashi T, Kario K.
  • Organizer: Joint Meeting on the European Society of Hypertension and International Society of Hypertension
  • Place of Presentation: アテネ
  • Year and Date: 2014-06-13 – 2014-06-16
• [Presentation] 離島住民における心血管リスク軽減を目的とした積極的減塩指導の有効性 (2014)
  • Author(s): 今泉悠希、江口和男、土橋卓也、苅尾七臣
  • Organizer: 第3回臨床高血圧フォーラム
  • Place of Presentation: 広島市
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] Long-Term Trend and Variability of Urinary Salt Excretion in Hypertensive Patients (2013)
  • Author(s): Sakaki M, Tsuchihashi T, Oniki H, Arakawa K.
  • Organizer: 23rd European Meeting on Hypertension
  • Place of Presentation: Milan
• [Presentation] 食塩摂取量の評価に基づく減塩指導 (2013)
  • Author(s): 土橋卓也
  • Organizer: 第3回臨床高血圧フォーラム
  • Place of Presentation: 東京
  • Invited
• [Presentation] 高血圧患者の減塩指導―簡易食事調査および随時尿による食塩排泄量評価の併用の有用性 (2013)
  • Author(s): 亀田和花子、福井浩子、榊美奈子、荒川仁香、土橋卓也、鬼木秀幸
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
• [Presentation] 高血圧患者における簡易食事調査票「塩分チェックシート」の妥当性についての検討 (2013)
  • Author(s): 福井浩子、亀田和花子、榊美奈子、荒川仁香、鬼木秀幸、土橋卓也
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
• [Presentation] 日本の減塩活動の現状と展望 (2013)
  • Author(s): 土橋卓也
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 食事調査による北部九州地域の離島住民の食塩摂取量とその関連因子の検討 (2012)
  • Author(s): 増田香織、池本美智子、今泉悠希、鬼木秀幸、清原嘉奈子、土橋卓也
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
• [Presentation] 単回の食塩摂取量測定は長期的食塩摂取の指標となり得るか？ (2012)
  • Author(s): 土橋卓也、鬼木秀幸、清原嘉奈子、荒川仁香、大田祐子
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
• [Presentation] 高血圧患者における食塩摂取量の時代的推移と減塩指導効果 (2012)
  • Author(s): 鬼木秀幸、土橋卓也、清原嘉奈子、大田祐子
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
• [Presentation] 離島住民における食塩摂取量と血圧管理状況の検討 (2012)
  • Author(s): 今泉悠希、江口和男、土橋卓也、苅尾七臣
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
• [Presentation] High salt intake promotes a decline in renal function in hypertensive patients: A 10-year observational study. (2012)
  • Author(s): Ohta Y, Tsuchihashi T, Kiyohara K, Oniki H
  • Organizer: 24th Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney, Australia
• [Book] 日本高血圧学会 減塩委員会報告 2012 （３）高血圧管理における食塩摂取量の評価と応用 (2012)
  • Author(s): 土橋卓也、甲斐久史、日下美穂、川村実、松浦秀夫、三浦克之、安東克之、丸山智美、早渕仁美、高木洋子、中東教江、佐藤敏子、河野雄平
  • Publisher: 日本高血圧学会