| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Xanthan gum is a polysaccharide produced by Xanthomonas campestris and widely used as food thickening agent. We examined cytokine productions in mouse macrophage-like cell line (J774.1) and in mouse primary spleen cells by xanthan gum. The production of interleukin (IL)-12 in J774.1 cells was enhanced by xanthan gum. In primary spleen cells from C3H/HeN [sensitive to lipopolysaccharide (LPS)] mice, the productions of IL-12 and interferon-γ were enhanced by xanthan gum, LPS and heat-killed Lactobacillus plantarum. These results suggested that xanthan gum induces cell-mediated immune response promoted by T helper 1 type cells. Therefore, xanthan gum as well as lactic acid bacterium has also function to protect decrease of cellular immunity in aging.
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