Effect of folic acid and folic acid-containing foods against oxidative damage of human vascular endothelial cells

Research Project

Project/Area Number	24500956
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Eating habits, studies on eating habits
Research Institution	Doshisha Women's College of Liberal Arts
Principal Investigator	MURAKAMI Megumi 同志社女子大学, 生活科学部, 准教授 (80340769)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords	葉酸 / 抗酸化性 / 血栓溶解性 / ヒトさい帯静脈血管内皮細胞 / アスパラガス / ビタミンB12 / 過酸化水素 / Huvec / 細胞生存率 / 血管内皮細胞
Outline of Final Research Achievements	Standards of folic acid has been shown to have antioxidant properties, folic acid contained in foods was also revealed to have similar anti-oxidative properties. Its antioxidant is to be exerted against oxidative damage of vascular endothelial cells was suggested, the effect was weak. In terms of stroke prevention, we examined the thrombolytic properties of folic acid using the fibrin plate method is a thrombosis model. As a result, were observed thrombolytic the standards of folic acid. However, thrombolytic was observed in folic acid that is extracted from asparagus. Thus, may show some effect on thrombus folic acid contained in the food has been suggested.