Screening of novel therapeutic molecules against neurodegenerative diseases via modulation of Hdac activity
| Project/Area Number |
24500972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Yamanashi |
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Principal Investigator |
NAGAI Kaoru 山梨大学, 総合研究部, 准教授 (20340953)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 機能性食品 / ヒストン脱アセチル化酵素 / 認知症予防 / 健康と食生活 / 神経変性疾患予防 |
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| Outline of Final Research Achievements |
By screening of Hdac inhibitory molecules, we found that Brazilian propolis extract (BPE) showed Hdac inhibitory effect. BPE also protected neuronal cells from endoplasmic reticulum stress induced cell death, which causes most of the neurodegenerative diseases.
We studied the Hdac modulating effects of branched fatty acid phytanic acid (PA), which is a metabolic intermediate of chlorophyll in beef and dairy products. Although generally fatty acids were reported to show Hdac inhibitory effects, PA showed Hadc activating effect. And PA induced neuronal cell death. During this study, we found that Hdac modulation associated with mitochondrial activity in neuronal cells. Our data suggests that the mitochondrial activations might be involved in the neuroprotective functions of Hdac inhibitory molecules.
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Report
(4 results)
Research Products
(16 results)
