Vitamin and chronic obstructive airway disease
| Project/Area Number |
24500976
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
YAMASAKI Akira 鳥取大学, 医学部附属病院, 講師 (70325009)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | ビタミン / トコトリエノール / 気道平滑筋細胞 / 閉塞性肺疾患 / 気管支喘息 |
|---|
| Outline of Final Research Achievements |
The relationships among oxidative stress marker, serum vitamin levels and phisical activity index in patients with chronic airway disease were studied. The serum vitamin levels were not related to physical activity index or oxidative stress levels. Therefore, the vitamin levels might not be related to oxidative stress at short time study. The long term and prospective study is needed to investigate the effects of vitamin on patients with airway diseases.
We also studied the effect of tocotrienol on human airway smooth muscle cells. Alfa, gamma and delta tocotrienol reduced airway smooth muscle cell proliferation and migration induced by PDGF-BB. This inhibitory effect is mediated by inhibtion of RhoA activation. We also found that gamma tocotrienol inhibited collagen I and fibronectin expression increased by TGF-beta1. These results indicate that tocotrienol could have benifical effects for airway remodeling in asthma by inhibiting several functions of airaway smooth muscle cells.
|
Report
(4 results)
Research Products
(6 results)
-
[Journal Article] gamma-tocotrienol reduces human airway smooth muscle cell proliferation and migration2015
Author(s)
Harada T, Yamasaki A, Chikumi H, Hashimoto K, Okazaki R, Takata M, Fukushima T, Watanabe M, Kurai J, Halayko AJ, Shimizu E
-
Journal Title
Pulmonary Pharmacology & Therapeutics
Volume: 15
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
