| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
The relationships among oxidative stress marker, serum vitamin levels and phisical activity index in patients with chronic airway disease were studied. The serum vitamin levels were not related to physical activity index or oxidative stress levels. Therefore, the vitamin levels might not be related to oxidative stress at short time study. The long term and prospective study is needed to investigate the effects of vitamin on patients with airway diseases.
We also studied the effect of tocotrienol on human airway smooth muscle cells. Alfa, gamma and delta tocotrienol reduced airway smooth muscle cell proliferation and migration induced by PDGF-BB. This inhibitory effect is mediated by inhibtion of RhoA activation. We also found that gamma tocotrienol inhibited collagen I and fibronectin expression increased by TGF-beta1. These results indicate that tocotrienol could have benifical effects for airway remodeling in asthma by inhibiting several functions of airaway smooth muscle cells.
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