Biliary carcinogenesis based upon degradated phospholipids
| Project/Area Number |
24500977
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | Bile / Bile duct / phospholipids / lysolecithin / apoposis / SASP / hepatolithiasis / 胆管 / リゾリン脂質 / 膵胆管合流異常 / 胆管癌 / アポトーシス / 炎症性サイトカイン / 細胞老化 / 劣化脂質 / リゾレシチン / Ｇタンパク共役型受容体 / 胆管上皮 / ＳＡＳＰ |
|---|
| Outline of Final Research Achievements |
In biliary diseases, biliary lysophosphatidylcholine (LPC) level is increased, LPC exhibited cytotoxicity with significant induction of apoptosis. Here, the influence of LPC on cholangiocytes was focussed in the light of cellular senescence and its contribution to carcinogenesis. Treatment of human cholangiosytes with LPC demonstrated cytotoxicity with significant ROS generation. In keeping with this change, LPC provoked oxidative DNA injury while the gene expressions of DNA repair enzyme remained unchanged. Microarray analysis identified differentially regulated genes in response to LPC, which included the components of senescence-associated secretory phenotype (SASP). Based upon these data, cholangiocyte senescence and SASP caused by LPC via induction of oxidative stress are an important pathogenic mechanism in the development of biliary tract cancer.
|
Report
(4 results)
Research Products
(25 results)
-
[Journal Article] Cholangiocyte senescence caused by lysophosphatidylcholine as a potential implication in carcinogenesis.2015
Author(s)
Shimizu R, Kanno K, Sugiyama A, Ohata H, Araki A, Kishikawa N, Kimura Y, Yamamoto H, Kodama M, Kihira K, Tazuma S.
-
Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 22
Issue: 9
Pages: 675-682
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Classification of biliary tract cancers established by the Japanese Society of Hepato-Biliary-Pancreatic Surgery: 3(rd) English edition.2015
Author(s)
Miyazaki M, Ohtsuka M, Miyakawa S, Nagino M, Yamamoto M, Kokudo N, Sano K, Endo I, Unno M, Chijiiwa K, Horiguchi A, Kinoshita H, Oka M, Kubota K, Sugiyama M, Uemoto S, Shimada M, Suzuki Y, Inui K, Tazuma S, Furuse J, Yanagisawa A, Nakanuma Y, Kijima H, Takada T.
-
Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 22
Issue: 3
Pages: 181-196
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
[Journal Article] Diagnostic workup for fever of unknown origin: a multicenter collaborative retrospective study2013
Author(s)
Naito T, Mizooka M, Mitsumoto F, Kanazawa K, Torikai K, Ohno S, Morita H, Ukimura A, Mishima N, Otsuka F, Ohyama Y, Nara N, Murakami K, Mashiba K, Akazawa K, Yamamoto K, Senda S, Yamanouchi M, Tazuma S, Hayashi J
-
Journal Title
BMJ Open
Volume: 20
Issue: 12
Pages: e003971-e003971
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] Hypertension enhances hepatic steatosis througt oxidative stress associated with down-regulated expressions of LXR and FXR :Implication to the future strategy for non-alcoholic fatty liver diseases(NAFLD) by nuclear receptor ligands2012
Author(s)
S.Tazuma,T.Ikuta,K.Kanno,M.Nakashima,A.Sugiyama,N.Kishikawa,H.Kodama,M.Okamoto,Y.Kikuchi,S.Kushihta,K.Yokobayashi,M.Mizooka,T.Saeki,K.Arihiro
Organizer
Falk Symposium
Place of Presentation
Austria
Related Report
-
-
-
-
-
[Book] 胆と膵2013
Author(s)
大屋敏秀、田妻進
Total Pages
3
Publisher
医学図書出版株式会社
Related Report
-
-
-
