Functional analysis of the lipid nourishment controlling the development of the brain
| Project/Area Number |
24500981
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Nayoro City University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Naomichi 静岡大学, 農学部, 教授 (10341079)
YAMAMOTO Ayako 名寄市立大学, 保健福祉学部, 研究員 (80414134)
西村 直道 名寄市立大学, 保健福祉学部, 教授 (10341679)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 脂質栄養 / 脳 / 神経細胞 / グリア細胞 / n-3系多価不飽和脂肪酸 / アストロサイト / オリゴデンドロサイト / 行動解析 / 細胞移動 / 脳発生 / 細胞分化 / 情動行動 |
|---|
| Outline of Final Research Achievements |
In the fetus and infant period, those nutrition depends on the nutritional state of maternal diet. Because brains develop well at these periods, it is affected by the nourishment state of the maternal diet. It is thought that the lipid, which is the component of the cell, affects the development of the brain, but the detailed function in the development of the brain at the fetus and infant period of the lipid nourishment is unclear. In this study, to elucidate a role of the lipid nourishment in the development of the brain of a fetus and infant brain, we performed morphological and behavioral analyses of the pups form the maternal that fed the n-3 polyunsaturated fatty acid deficient diet. As a result, we observed astrocyte decrease in the cerebral neocorex and emotional instability in the n-3 polyunsaturated fatty acid deficient pups.
|
Report
(4 results)
Research Products
(5 results)
