| Project/Area Number |
24500983
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Niigata Prefecture |
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Principal Investigator |
WATANABE Reiko 新潟県立大学, その他, 名誉教授 (70141348)
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| Co-Investigator(Renkei-kenkyūsha) |
KADOWAKI Motoni 新潟大学, 自然科学系, 教授 (90126029)
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| Research Collaborator |
KUBOTA Masatoshi 新潟大学, 超域学術院, 助教 (00595879)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 米胚乳タンパク質 / 米糠タンパク質 / ２型糖尿病 / 糖尿病性腎症 / 非肥満糖尿病モデルGKラット / 肥満糖尿病モデルZDFラット / 2型糖尿病 / GKラット / ＺＤＦラット / 腎糸球体障害度 / 肥満2型糖尿病モデル / ZDFラット / 尿中アルブミン / 2型糖尿病モデルGKラット |
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| Outline of Final Research Achievements |
Ameliorative effect of rice endosperm protein (REP) on diabetic nephropathy was suggested to be caused by the suppression of renal MCP-1 rise in non-obese, spontaneous type 2 diabetic Goto-Kakizaki rats. In Zucker Diabetic Fatty rats, which are an animal model of obese type 2 diabetes mellitus, dietary REP and rice bran protein (RBP) delayed in the progression of renal failure. In addition, REP and RBP markedly suppressed lipid accumulation in the liver and improved glucose homeostasis parameter such as hemoglobin A1c. The analysis of gene expression data of the liver and kidney obtained using microarray experiments showed both the effect of rice proteins on contributing to the increased expression of glycolytic enzyme-related genes in the liver and, in the kidney, the decrease of inflammatory gene expression, and the increase of oxidative stress-related gene expression.
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