Functionality of the nutrients for attenuation of fatty liver disease caused by overfeeding.
| Project/Area Number |
24500985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
KUWAHATA Masashi 京都府立大学, 生命環境科学研究科(系), 准教授 (30304512)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | ゼラチン / 加水分解物 / 肝線維化 / 血糖値 / 糖尿病 / 脂肪肝 / 肝障害モデルラット / ゼラチン加水分解物 / 病態栄養学 |
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| Outline of Final Research Achievements |
The non-alcoholic fatty liver disease (NAFLD) is a phenotype in the livers of the metabolic syndrome. The patients are often complicated with obesity and diabetes. It is known that progression of liver fibrosis deteriorates NAFLD to non-alcoholic steatohepatitis (NASH).
Present study found that supplementation of gelatin hydrolysate (GH) delayed hepatic fibrosis in rats with chronic liver disease. Furthermore, GH attenuated an increase in blood glucose level in rats with diabetes.
The GH may be effective as a functional ingredient controlling progression of metabolic syndrome and the fatty liver.
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Report
(4 results)
Research Products
(8 results)
