| Project/Area Number |
24500989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kagawa Prefectural College of Health Sciences |
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Principal Investigator |
KABUTO Hideaki 香川県立保健医療大学, 教養部, 教授 (00321266)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANUSHI Tomoko 香川県立保健医療大学, 教養部, 准教授 (40382395)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | パーキンソン病 / 6-ヒドロキシドーパミン / L-DOPA / スクアレン / スクアラン / ドーパミン / 酸化的障害 / 線条体 / Parkinson病 / 6-hydroxydopamine / squalene / squalane / dopamine |
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| Outline of Final Research Achievements |
We examined the effects of squalene (SQE) and squalene (SQA) on a 6-hydroxydopamine (6-OHDA) induced Parkinson’s diseases (PD) mouse model. SQE administration 7 days before 6-OHDA injection prevented a reduction in striatal dopamine (DA) levels, while the administration of SQA enhanced the levels. SQA increased a marker of lipid peroxidation. These results suggest that SQA increases oxidative damage in the striatum and exacerbates the toxicity of 6-OHDA, while SQE prevents it.
Then, we examined the effects of administration of SQE and L-DOPA, the most popular therapeutic medicine for treating PD, for 4 weeks following a single 6-OHDA injection. SQE inhibited 6-OHDA induced DA depression and father depression by L-DOPA with 6-OHDA. SQE and/or L-DOPA had no effect on antioxidants levels and enzyme activities. The effects of pre- and post- treatment SQE suggest its possible uses in the treatment of PD. More studies are needed to understand the mechanisms of these SQE effects.
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