| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
In this study, we investigated to clarify whether cocked rice (CR) improved the DSS-induced colitis of the mouse. We found that the oral CR improved a symptom of the colitis with the weight loss and MPO activity of the mouse. In addition, gene expression analysis of colon tissue by DNA microarrays, CR increased the expression of cell cycle-related genes. Furthermore, rice-derived peptides were considered to maintain the barrier function of the intestinal tissue that was induced inflammation. These results suggest that dietary CR may relieve the prevention and improvement of inflammatory bowel disease.
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