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Studies on the cross-talk among organs of anti-inflammatory effects by cereal intake and exploratory research of active components

Research Project

Project/Area Number 24500995
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionOtsuma Women's University

Principal Investigator

AOE Seiichiro  大妻女子大学, 家政学部, 教授 (90365049)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsメタボリックシンドローム / 大麦 / β-グルカン / 雑穀 / 肥満モデルマウス / 大麦β-グルカン / 腸内細菌叢 / 抗炎症マーカー / 短鎖脂肪酸 / クロストーク / β-グルカン / 脂肪組織 / 炎症 / 腸内細菌 / クロストリジウム / 消化管 / 肝臓 / 皮膚 / モチ麦
Outline of Final Research Achievements

Anti-inflammatory effects of barley beta-glucan intake on inflammation of liver, skin tissues as well as adipose tissues by modification of gut microbiota were studied. Compositions of brown rice, black rice, rye, oat were also analyzed and compared to the barley. These results indicated that parameters related to metabolic syndrome were deteriorated in the high fat diet by cross talk among dysbiosis, production of short chain fatty acid synthesis, large bowel and organs inflammation. Our results also indicated that high beta-glucan barley has protective effect on inflammation of organs by modification of gut microbiota compared to other cereals.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 5 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results)

  • [Journal Article] Effects of Softened <i>Kombu</i> Supplementation on Parameters Related to Metabolic Syndrome in Mice with Diet-induced Obesity2015

    • Author(s)
      山岸あづみ、工藤陽香、青江誠一郎
    • Journal Title

      Nippon Eiyo Shokuryo Gakkaishi

      Volume: 68 Issue: 3 Pages: 119-128

    • DOI

      10.4327/jsnfs.68.119

    • NAID

      130005077722

    • ISSN
      0287-3516, 1883-2849
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of liquid konjac on parameters related to obesity in diet-induced obese mice.2015

    • Author(s)
      Seiichiro Aoe, Haruka Kudo, Seiya Sakurai
    • Journal Title

      Bioscience, Biotechnology and Biochemistry

      Volume: 79 Pages: 1141-1146

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Ingestion of Barley Pancake on Postprandial Blood Glucose Levels2015

    • Author(s)
      笹岡 歩、河本高伸、青江誠一郎
    • Journal Title

      The Japanese Journal of Nutrition and Dietetics

      Volume: 73 Issue: 6 Pages: 253-258

    • DOI

      10.5264/eiyogakuzashi.73.253

    • NAID

      130005143550

    • ISSN
      0021-5147, 1883-7921
    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] Effect of Cooked White Rice with High β-glucan Barley on Appetite and Energy Intake in Healthy Japanese Subjects: A Randomized Controlled Trial.2014

    • Author(s)
      Aoe S, Ikenaga T, Noguchi H, Kohashi C, Kakumoto K, Kohda N.
    • Journal Title

      Plant Foods Hum Nutr.

      Volume: 69 Pages: 325-330

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 健常成人における大麦β-グルカン1 g含有クラッカーの食後血糖応答に及ぼす影響2014

    • Author(s)
      青江誠一郎, 野口洋樹, 池永武, 小梯知英子, 角元慶二, 甲田哲之
    • Journal Title

      薬理と治療

      Volume: 452 Pages: 687-693

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 大麦中のβ-グルカンの有無ならびに搗精処理が食餌性肥満モデルマウスのメタボリックシンドローム関連指標に及ぼす影響2015

    • Author(s)
      青江誠一郎、加藤美智子、山中千恵美、工藤陽香、一ノ瀬靖則、神山紀子、小前幸三、髙橋飛鳥、吉岡藤治、柳澤貴司
    • Organizer
      日本食物繊維学会第20回学術集会
    • Place of Presentation
      伊那食品工業株式会社
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 内臓脂肪蓄積に対する高ベータグルカン大麦ご飯の影響:プラセボ対照二重盲検比較試験2015

    • Author(s)
      青江誠一郎、吉岡藤治、柳沢貴司
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大麦β-グルカンの新機能と腸内代謝2015

    • Author(s)
      青江誠一郎
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大麦の機能性研究の最新エビデンス2015

    • Author(s)
      青江誠一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      門司港ホテル
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Effects of beta-glucan content and barley pearling process on the parameters related to metabolic syndrome in diet-induced obese mice.2015

    • Author(s)
      Seiichiro Aoe, Yasunori Ichinose, Noriko Kohyama, Kozo Komae, Asuka Takahashi, Toji Yoshioka, Takashi Yanagisawa
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Pacifico Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 穀物食物繊維の機能性研究に関する最新情報2014

    • Author(s)
      青江誠一郎
    • Organizer
      日本食物繊維学会第19回学術集会
    • Place of Presentation
      大妻女子大学
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 食物繊維と腸から考えるアンチエイジング食2014

    • Author(s)
      青江誠一郎
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 大麦または大麦β-グルカン抽出物の摂取が食餌性肥満マウスの耐糖能に及ぼす影響2014

    • Author(s)
      加藤美智子、小前幸三、一ノ瀬靖則、吉岡藤治、青江誠一郎
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 高炭水化物および高脂肪食の摂取が摂食皮膚炎モデルマウスに及ぼす影響

    • Author(s)
      小林悦子、高波嘉一、青江誠一郎
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食中の大麦由来β-グルカン含量がマウスの耐糖能と腹腔内脂肪蓄積に及ぼす影響

    • Author(s)
      加藤美智子、椿和文、久下高生、青江誠一郎
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 雑穀の摂取が食餌性肥満マウスの耐糖能に及ぼす影響

    • Author(s)
      加藤美智子、青江誠一郎
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 大麦β-グルカンの健康価値と最新の研究動向

    • Author(s)
      青江誠一郎
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 大麦または大麦β-グルカン抽出物の摂取が食餌性肥満マウスの耐糖能に及ぼす影響

    • Author(s)
      加藤美智子、小前幸三、一ノ瀬靖則、吉岡藤治、青江誠一郎
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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