Effects of coffee consumption on steroid metabolisms linked to life-style related disorders.
| Project/Area Number |
24500996
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | コーヒー / 生活習慣病 / ステロイドホルモン / 大腸がん / 乳がん / 前立腺がん / 神経ステロイド / がん / 予防 / エストロゲン / 肥満 / 脂肪細胞 / miRNA / ras遺伝子 / 硫酸転移酵素 / SULT1E1 |
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| Outline of Final Research Achievements |
Coffee is one of the world’s most commonly consumed beverages. Recent epidemiological studies show that coffee consumption has been associated with a lower risk of several life-style related disorders such as diabetes, obesity, cancers and dementia. On the other hand, dysfunction of metabolism of steroids such as stress hormone, estrogens and androgens is closely linked to the risk of incidence of these disorders. We investigated effects of coffee on the metabolism of these steroid hormones in human cancer cells such as colon, breast, prostate cancers and glioma. We obtained results suggesting protective effects of coffee on colon and breast cancers but not to prostate cancer. In addition, our result suggest that coffee may increase production of neurosteroids that act to lower the risk of dementia.
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Report
(4 results)
Research Products
(34 results)
