Does the insulin-inducible transcription factor SHARP gene family involve in down-regulation of the blood glucose level?
| Project/Area Number |
24501002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Matsumoto University |
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Principal Investigator |
YAMADA KAZUYA 松本大学, 健康科学研究科, 教授 (20263238)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | SHARP 遺伝子 / インスリン / 糖尿病 / 血糖低下 / シグナル伝達 / 食品成分 / AICAR / protein kinase C / 転写抑制 / 転写因子 / 遺伝子発現 |
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| Outline of Final Research Achievements |
SHARP-2, an insulin-inducible transcriptional repressor, involves in the down-regulation of the blood glucose level by repressing the transcription of the gluconeogenic enzyme gene.
In this study, we showed that SHARP-1, another SHARP family gene, also contributed the down-regulation of the blood glucose level by insulin. We then showed signal transduction pathways mediating the induction of expression of both the SHARP-1 and the SHARP-2 genes by insulin or the SHARP-2 gene by AICAR. Furthermore, we identified both an isoflavone-metabolite (S)-Equol and a green tea catechin as food constituents mimicking the insulin action and analyzed the signal transduction pathways.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Insulin stimulates the expression of the SHARP-1 gene via multiple signaling pathways.2014
Author(s)
Takagi, K., Asano, K., Haneishi, A., Ono, M., Komatsu, Y., Yamamoto, T., Tanaka, T., Ueno, H., Ogawa, W., Tomita, K., Noguchi, T., and Yamada, K.
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Journal Title
Horm. Metab. Res.
Volume: 46
Issue: 06
Pages: 397-403
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Analysis of regulatory mechanisms of an insulin-inducible SHARP-2 gene by (S)-Equol.2012
Author(s)
Haneishi, A., Takagi, K., Asano, K., Yamamoto, T., Tanaka, T., Nakamura, S., Noguchi, T., and Yamada, K.
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Journal Title
Arch. Biochem. Biophys.
Volume: 525
Issue: 1
Pages: 32-39
DOI
Related Report
Peer Reviewed
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