| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
SHARP-2, an insulin-inducible transcriptional repressor, involves in the down-regulation of the blood glucose level by repressing the transcription of the gluconeogenic enzyme gene.
In this study, we showed that SHARP-1, another SHARP family gene, also contributed the down-regulation of the blood glucose level by insulin. We then showed signal transduction pathways mediating the induction of expression of both the SHARP-1 and the SHARP-2 genes by insulin or the SHARP-2 gene by AICAR. Furthermore, we identified both an isoflavone-metabolite (S)-Equol and a green tea catechin as food constituents mimicking the insulin action and analyzed the signal transduction pathways.
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