| Project/Area Number |
24501003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aichi Gakusen University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOI Kayoko 静岡県立大学, 大学院生活健康科学研究科, 教授 (10162728)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ホルモン依存性がん / エストロゲン代謝 / がん化学予防 / フラボノイド / DNA損傷 / カテコールエストロゲン / エストロゲン / がん予防 / 食品因子 / ホルモン依存性疾患 / メトキシフラボノイド |
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| Outline of Final Research Achievements |
A principal factor of common to all endocrine-related risk factors is the prolonged exposure to estrogens. In particular, estrogens play a crucial role in the development and evolution of human breast cancer. In the metabolism of estrogens, hydroxylation is mediated by cytochrome P450, such as CYP1A1, 1A2 and 1B1. Quinone intermediates derived by oxidation of 4-hydroxy-estrogens have been reported to react with purine bases of DNA to form depurinating adducts that generate highly mutagenic apurinic sites. Futhermore, the metabolites of hydroxy-estrogens may also generate potentially mutagenic oxygen radicals.
A dietary methoxyflavonoid inhibited DNA damage induced by the carcinogenic endogenous estrogen metabolite, 4-hydroxy-estrogen. In this study, methoxyflavonoid showed inhibitory effects on DNA damage derived from estrogen metabolites. This indicates that such methoxyflavonoids may be a chemopreventive modulator involved in carcinogenesis such as in breast cancer.
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