| Project/Area Number |
24501010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yuji 近畿大学, 医学部附属病院, 講師 (00465650)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 酸化ストレス / 脂質代謝 / Nrf2 / 脂肪酸 / 脂質組成 / 高コレステロール食 / ezetimibe / 脂肪酸組成 / 大豆油 / ラード / 魚油 |
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| Outline of Final Research Achievements |
The crosstalk between lipid metabolism and regulation of oxidative stress by Nrf2-keap1 system was examined. ①Dietary fatty acid composition affected lipid metabolism , furthermore transcription factor Nrf2 influenced activation of fatty acid oxidation, cholesterol excretion and catabolism by n-3 unsaturated fatty acid rich fish oil. ②There was correlations between cholesterol absorption and Nrf2 system. The changes of the quantity of cholesterol absorption affected gene expression related to fatty acid metabolism (FAS, ACC1, SREBP-1c, SCD-1c and CD36), cholesterol transport (Abcg5/abcg8), bile acid synthesis (Cyp7a1) and Nrf2 participated in these lipid metabolism which were controlled by LXRα. ③The Nrf2 activator influenced lipid metabolism. 6-methylsulfinylhexylisothianate (6-MSITC), one of Nrf2 activators, controlled lipid deposition and cytokine production in the liver. High fat induced fatty liver was improved through Nrf2 system.
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