Mechanistic study for the anti-cancer effects of phytochemicals against breast and colon cancers
| Project/Area Number |
24501020
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Nakamura Gakuen College |
|---|
Principal Investigator |
NAKANO Shuji 中村学園大学, 栄養科学部, 教授 (40164248)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKESHIMA Mikako 中村学園大学, 栄養科学部, 講師 (00241183)
ONO Misaki 中村学園大学, 栄養科学部, 助教 (10441726)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 乳癌 / フィトケミカル / 抗癌作用 / 分子機序 / アポトーシス / 増殖抑制 / 一次予防 / シグナル伝達 / 制がん効果 / 大腸癌 / 増殖制御 / 乳癌細胞 / 細胞周期 / 癌遺伝子 / イソフラボン / クルクミン |
|---|
| Outline of Final Research Achievements |
We investigated the molecular mechanism of anticancer activities of phytochemicals against different subtypes of human breast cancer cells, and examined whether certain phytochemicals can be used as a preventive measure against breast cancer using rat model of EMS-induced mammary carcinoma. Phytochemicals used were isoflavones, curcumin, lycopene, nobiletin, and resveratrol. Although the molecular mechanism varies depending phytochemicals, they excerted anticancer activity by affecting intracellular signaling proteins associated with proliferation and apoptosis. In animal model, isoflavones and lycopene has been found to inhibit breast cancer development. Phytochemicals would be thus considered not only be effective in the primary prevention of breast cancer, but also be active in inhibiting the growth and progression of breast cancer.
|
Report
(4 results)
Research Products
(54 results)
-
-
-
[Journal Article] Discontinuation of leisure time impact-loading exercise is related to reduction of a calcaneus quantitative ultrasound parameter in young adult Japanese females: a 3-year follow-up study.2014
Author(s)
Nakazono E., Miyazaki H., Abe S., Imai K., Masuda T., Iwamoto M., Moriguchi R., Ueno H., Ono M., Yazumi K., Moriyama K., Nakano S., and Tsuda H.
-
Journal Title
Osteoporos Int.
Volume: 25
Issue: 2
Pages: 485-495
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 肥満中年女性におけるゆるやかな減量の効果2014
Author(s)
五郎丸瞭子, 岩本昌子, 中尾晶子, 宮崎瞳, 今井克己, 阿部志麿子, 森口里利子, 津田博子, 中園栄里, 小野美咲, 上野宏美, 中野修治
Organizer
第61回日本栄養改善学会学術総会
Place of Presentation
横浜
Year and Date
2014-08-21
Related Report
-
-
[Presentation] 卒業10年後の健診結果に影響を及ぼす大学在学時の食事因子―卒後追跡調査から―2014
Author(s)
上野宏美, 宮崎瞳, 今井克己, 阿部志磨子, 増田隆, 森口里利子, 津田博子, 岩本昌子, 中園栄里, 小野美咲, 森山耕成, 大部正代, 大無田恵美, 岩本華奈, 五郎丸瞭子, 中野修治
Organizer
第68回日本栄養・食糧学会大会
Place of Presentation
札幌
Year and Date
2014-06-01
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
