| Project/Area Number |
24501029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
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Principal Investigator |
SAKANE Naoki 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究室長(予防医学) (40335443)
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| Co-Investigator(Kenkyū-buntansha) |
TSUZAKI Kokoro 独立行政法人国立病院機構, 京都医療センター臨床研究センター, 臨床研究企画運営部研究員 (80450881)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病 / 妊娠 / 周産期 / 予防 / 食事 / 体重 / 喫煙 |
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| Outline of Final Research Achievements |
The aim of this study is to develop a structured simple dietary support program for preventing gestational diabetes（GDM）. 1) In the pregnancy registry, women with GDM had greater amount of bleeding during delivery than women without GDM. Predictive factors for infant over 3,500g of weight were body mass index (BMI) in the non-pregnant conditions and weight gain during pregnancy. Predictive factors for low birth weight were low BMI, less weight gain during pregnancy, and smoking. 2) We developed genetic sets of DNA methylation for GDM in maternal and umbilical cord blood leukocytes. 3) We randomized obese diabetic subjects into an intervention group including educational classes on lifestyle modification incorporating the healthy plate or a control group. Subjects in the intervention group had a greater weight change from baseline to the end of the 3-month intervention period. This program may effectively reduce body weight in pregnant women with obesity.
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