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Study for the effects of dietary vegetable oil intake on lifestyle-related disease using transcriptome analysis

Research Project

Project/Area Number 24501030
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

NAITO Yukiko  独立行政法人国立循環器病研究センター, 研究所, 室長 (80426428)

Co-Investigator(Kenkyū-buntansha) IWAI Naoharu  独立行政法人国立循環器病研究センター, 研究所, 部長 (30242978)
Co-Investigator(Renkei-kenkyūsha) KI Asahi  独立行政法人国立循環器病研究センター, 研究所, 流動研究員 (90535048)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords食用油 / 生活習慣病 / 血圧 / モデル動物 / カノーラ油
Outline of Final Research Achievements

We have already confirmed that canola oil intake shortens the survival time of stroke prone spontaneously hypertensive rats (SHRSP), which is a kind of lifestyle-related disease model animal. In this background, progressive promotion of the hypertension induced changes, such as injury of heart and kidney was observed. In this study, to clarify the mechanism, SHRSP were fed diets containing canola oil or soybean oil (control), and the experiment was conducted by focusing on gene expression and blood pressure changes. In the continuous blood pressure measurement, blood pressure of the light period was increased in the canola oil group. However, the relationship between the expression of catecholamine metabolism-related genes and the blood pressure changes did not become clear.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Presentation (8 results)

  • [Presentation] 肥満糖尿病モデルマウスにおけるn-3多価不飽和脂肪酸摂取の疾患進行に与える影響2015

    • Author(s)
      内藤由紀子、翁華春、岩井直温
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      愛知
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病マウスにおける機能性食用油の4週間摂取の影響2014

    • Author(s)
      内藤由紀子、大原直樹、岩井直温
    • Organizer
      日本脂質栄養学会第23回大会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満糖尿病マウスにおける3種類の機能性食用油4週間摂取の影響2014

    • Author(s)
      内藤由紀子、柳川成章、大原直樹、岩井直温
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖尿病モデルマウスにおける不飽和脂肪酸補給の疾患進行に与える影響2013

    • Author(s)
      内藤由紀子、馬嘯、遠藤恒介、紀旭、翁華春、岩井直温
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 機能性食用油の安全性に関する研究 ―食用油摂取がステロイドホルモン代謝に及ぼす影響―2013

    • Author(s)
      大原直樹、内藤由紀子、岩井直温
    • Organizer
      日本脂質栄養学会第22回大会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳卒中易発症高血圧自然発症ラットにおける3種の機能性食用油摂取の影響2013

    • Author(s)
      内藤由紀子、遠藤恒介、翁華春、大原直樹、岩井直温
    • Organizer
      日本脂質栄養学会第22回大会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of ω-3 and ω-6 fatty acid supplementation on regulation of blood glucose in mice2013

    • Author(s)
      Yukiko Naito, Xiao Ma, Kosuke Endo, Xu Ji, Huachun Weng, Naoharu Iwai
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 菜種(カノーラ)油摂取が脳卒中易発症 高血圧自然発症ラット(SHRSP)の病態悪化を促進する機序2012

    • Author(s)
      小野田早恵、内藤由紀子、立花滋博、河村さやか、大原直樹、吉川真衣、新美まどか、川口真帆、宮澤大介、安井裕子、山田和代、奥山治美
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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