Elucidation of the mechanisms that control aging and cancer by chromatin remodeling
| Project/Area Number |
24501305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Carcinogenesis
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 教授 (80291508)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発がん / エピジェネティクス |
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| Outline of Final Research Achievements |
Cellular senescence of tissue stem cells are deeply involved in the onset of age-related diseases, such as neurodegenerative diseases and cancer. We found that the chromatin remodeling factor CHD8 binds to tumor suppressor protein p53 and inhibits p53-mediated apoptosis, which plays an important role in organogenesis during embryogenesis. We next revealed that CHD8 inhibits not only p53-induced apoptosis but also cellular senescence and exhibits potent transforming activity. More recently, CHD8 is identified as the most frequently mutated gene in autism spectrum disorder (ASD), which creates a big sensation all over the world. Furthermore, we found that CHD8 is essential for maintenance of neural stem cells and mice heterozygous for CHD8 gene were found to manifest ASD-like phenotypes.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] Regulation of iron metabolism by the FBXL5-IRP2 axis is essential for neural stem cell homeostasis2014
Author(s)
Yamauchi, T., Nishiyama, M., Moroishi, T., Muto, Y., Nakayama, K. I.
Organizer
Annual Meeting of Grants-in-Aid for Scientific Research, “Ubiquitin neobiology”, Symposium for young ubiquitin researcher, International Institute for Advanced Studies
Place of Presentation
京都
Year and Date
2014-11-12
Related Report
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[Presentation] Proteolytic control of iron metabolism by the ubiquitin ligase FBXL5 and its suppressive role in carcinogenesis in the liver2014
Author(s)
Muto, Y., Nishiyama, M., Moroishi, T., Yamauchi, T., Nakayama, K. I.
Organizer
Annual Meeting of Grants-in-Aid for Scientific Research, “Ubiquitin neobiology”, Symposium for young ubiquitin researcher, International Institute for Advanced Studies
Place of Presentation
京都
Year and Date
2014-11-12
Related Report
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[Presentation] The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism in Vivo
Author(s)
Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K., Nakayama, K. I.
Organizer
The Joint Symposium of the 7th International Symposium of the Institute Network and the 45th IDAC Symposium, the 2nd Symposium for Joint Usage/Research Center of Aging
Place of Presentation
仙台
Related Report
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