| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Cellular senescence of tissue stem cells are deeply involved in the onset of age-related diseases, such as neurodegenerative diseases and cancer. We found that the chromatin remodeling factor CHD8 binds to tumor suppressor protein p53 and inhibits p53-mediated apoptosis, which plays an important role in organogenesis during embryogenesis. We next revealed that CHD8 inhibits not only p53-induced apoptosis but also cellular senescence and exhibits potent transforming activity. More recently, CHD8 is identified as the most frequently mutated gene in autism spectrum disorder (ASD), which creates a big sensation all over the world. Furthermore, we found that CHD8 is essential for maintenance of neural stem cells and mice heterozygous for CHD8 gene were found to manifest ASD-like phenotypes.
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