| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The incidence of tumors in HIV-infected individuals are still high compared to non-infected population, although longevity of HIV-infected individuals had been prolonged due to the development of anti-HIV drug and therapy. Especially, B-cell lymphoma was reported as 20% of HIV-infected individuals, which is very high incidence. Therefore, we hypothesized that genomic instability might be potentially existed in HIV-infected individuals before the tumoregenesis. In this study, we found genomic instability both in experiments using cell lines and in prematured B-cell lymphocytes using clinical samples from HIV-1 patients without malignancies, suggesting potential risks of malignancy.
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