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Identification of the role of Vasohibin-2 in tumor malignancy and its application in novel cancer therapy

Research Project

Project/Area Number 24501309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionTohoku University

Principal Investigator

SUZUKI YASUHIRO  東北大学, 加齢医学研究所, 助教 (60332277)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsVasohibin / 上皮間葉転換 / 癌悪性化 / 炎症 / 血管新生 / miR-200 / 胃癌 / 脂質結合 / miRNA / 癌幹細胞 / 炎症性サイトカイン / 転移
Outline of Final Research Achievements

In this study, the role of Vashibin-2 (VASH2) in tumor malignancy was analyzed. The expression level of VASH2 in cancer cells was regulated by miR-200 family, and affected cancer cell migration and invasion mediated by epithelial-mesenchymal transition-related (EMT) gene expressions. Purified VASH2 protein selectively interacted with some types of phospholipids (e.g. cardiolipin and phosphatidic acid), and its interaction affected the extracellular secretion of VASH2 protein from cancer cells. The expression of Vash2 mRNA was significantly increased in mouse gastric tumors compared with normal mucosa. Knocking out of Vash2 gene suppressed gastric tumor growth accompanying the down-regulation of gene expressions related to cancer growth, inflammation, and angiogenesis (e.g. Epiregulin and Interleukin-11). These results suggest that VASH2 may influence tumor malignancy via EMT and inflammation beside its role in angiogenesis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012 Other

All Presentation (7 results) Remarks (4 results)

  • [Presentation] Vasohibinを見つめ直すと...2015

    • Author(s)
      鈴木康弘
    • Organizer
      第1回血管生物若手研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-06 – 2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of Vasohibin-2 in gastric cancer and a new perspective of Vasohibin family2015

    • Author(s)
      Yasuhiro Suzuki, Yasufumi Sato
    • Organizer
      The 10th Vasohibin Meeting
    • Place of Presentation
      宮城
    • Year and Date
      2015-01-10 – 2015-01-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of Vasohibin-2 in tumor growth and angiogenesis2014

    • Author(s)
      Yasuhiro Suzuki, Shuji Kitahara, Yasufumi Sato
    • Organizer
      The 9th International Symposium of the Institute Network
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Expression of pro-angiogenic VASH2 and its novel roles in cancer cells2014

    • Author(s)
      Yasuhiro Suzuki, Takahiro Koyanagi, Yoshifumi Takahashi, Yasushi Saga, Mitsuaki Suzuki, Yasufumi Sato
    • Organizer
      The 18th International Vascular Biology Meeting (IVBM2014)
    • Place of Presentation
      京都
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] vasohibin-2を標的とした悪性腫瘍に対する新規抗血管新生療法の開発2013

    • Author(s)
      小柳貴裕・鈴木康弘・小林美穂・宮下浩輝・嵯峨泰・鈴木光明・佐藤靖史
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Vasohibin-2の抑制が消化管における自然発症腫瘍に影響を及ぼすか?2013

    • Author(s)
      北原秀治・鈴木康弘・森島正惠・吉井明日香・松居彩・佐藤靖史・江崎太一
    • Organizer
      第21回血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Regulation of VASH2 expression by miR-200 family and its role in cancer cells2012

    • Author(s)
      Yasuhiro Suzuki, Takahiro Koyanagi, Miho Kobayashi, Hiroki Miyashita, Yasushi Saga, Mitsuaki Suzuki, Yasufumi Sato
    • Organizer
      The 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization
    • Place of Presentation
      あわぎんホール(徳島県)
    • Related Report
      2012 Research-status Report
  • [Remarks] 東北大学 加齢医学研究所 腫瘍循環分野

    • URL

      http://www2.idac.tohoku.ac.jp/dep/vascbio/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究活動 腫瘍循環研究分野

    • URL

      http://www.idac.tohoku.ac.jp/ja/activities/research/vascular_biology/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所腫瘍循環研究分野ホームページ

    • URL

      http://www2.idac.tohoku.ac.jp/dep/vascbio/

    • Related Report
      2013 Research-status Report
  • [Remarks] 東北大学加齢医学研究所腫瘍循環研究分野ホームページ

    • URL

      http://www2.idac.tohoku.ac.jp/dep/vascbio/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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