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Generation of cancer stem cell library from iPS cells for development of drug screening system

Research Project

Project/Area Number 24501315
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionOkayama University

Principal Investigator

MIZUTANI Akifumi  岡山大学, 自然科学研究科, 助教 (50598331)

Co-Investigator(Kenkyū-buntansha) SENO Masaharu  岡山大学, 大学院自然科学研究科, 教授 (90243493)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsがん幹細胞 / 薬剤スクリーニング / iPS / ドラッグデリバリー / がん幹細胞ニッチ / エクソソーム / 標的化薬剤 / スクリーニング / アポトーシス / iPS細胞 / 脂肪肉腫 / ニッチ
Outline of Final Research Achievements

In the study of cancer and development of new anticancer drug, cancer stem cells (CSCs) are now considered to be important targets. In this study, we developed a drug screening system using various mouse iPS-derived cancer stem model cells (miPS-CSCs). In addition, we analyzed the gene expression profiles of miPS-CSCs, which focus on cell surface protein to use targeted drug delivery system. Comparison with normal tissue distribution, we nominated several candidate genes for tissue specific targeting.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles2014

    • Author(s)
      Yan T, Mizutani A, Chen L, Takaki M, Hiramoto Y, Matsuda S, Shigehiro T, Kasai T, Kudoh T, Murakami H, Masuda J, Hendrix MJ, Strizzi L, Salomon DS, Fu L, Seno M.
    • Journal Title

      Journal of Cancer

      Volume: 5 Issue: 7 Pages: 572-584

    • DOI

      10.7150/jca.8865

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cancer stem cells maintain a hierarchy of differentiation by creating their niche.2013

    • Author(s)
      Matsuda S, Yan T, Mizutani A, Sota T, Hiramoto Y, Prieto-Vila M, Chen L, Satoh A, Kudoh T, Kasai T, Murakami H, Fu L, Salomon DS, Seno M
    • Journal Title

      Int J Cancer

      Volume: 00 Issue: 1 Pages: 0-0

    • DOI

      10.1002/ijc.28648

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A cancer stem cell model: an insight into the conversion of induced pluripotent stem cells to cancer stem-likecells.2013

    • Author(s)
      Mizutani A, Chen L, Kasai T, Kudoh T, Murakami H, Fu L, Seno M
    • Journal Title

      Cancer Stem Cells (Ed. Rajasekhar K. Vinagolu), Wiley-Blackwell

      Volume: 未定

    • Related Report
      2012 Research-status Report
  • [Journal Article] Cancer stem cells derived from mouse induced pluripotent stem cells.2013

    • Author(s)
      Murakami H, Mizutani A, Chen L, Kasai T, Kudoh T, Fu L, Seno M.
    • Journal Title

      Stem cells and cancer stem cells (Ed. M.A. Hayat), Springer

      Volume: 未定

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] マウスiPS細胞から作るがん幹細胞モデル2013

    • Author(s)
      笠井智成,陳 凌,工藤孝幸,水谷昭文,妹尾昌治
    • Journal Title

      細胞工学

      Volume: 32 Pages: 330-330

    • Related Report
      2012 Research-status Report
  • [Journal Article] A Model of Cancer Stem Cells Derived from Mouse Induced Pluripotent Stem Cells2012

    • Author(s)
      Ling Chen, Masashi Okada, et al
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 4 Pages: e33544-e33544

    • DOI

      10.1371/journal.pone.0033544

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] がん幹細胞ニッチにおけるがん幹細胞の自己複製制御機構の解析2014

    • Author(s)
      平本祐樹、渡邉直哉、松田修一、Yan T、Marta P Vila、水谷昭文、村上宏、笠井智成、妹尾昌治
    • Organizer
      第37 回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tumor derived exosome/microvesicles convert mouse iPS cells to cancer stem-like cells2014

    • Author(s)
      Yan T, Mizutani A, Chen L, Murakami H, Seno M
    • Organizer
      第73 回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tumor derived exosomes/microvesicles convert mouse induced pluripotent stem cells to cancer stem cells2014

    • Author(s)
      Yan T, Mizutani A, Chen L, Murakami H, Seno M
    • Organizer
      Exosomes & Single cell Analysis Summit
    • Place of Presentation
      アメリカ サンディエゴ
    • Year and Date
      2014-09-18 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cancer stem cells maintain a hierarchy of differentiation by creating their niche2014

    • Author(s)
      Mizutani A, Matsuda S, Yan T, Prieto-Vila M, Chen L, Satoh A, Kasai T, Masuda J, Kudoh T, Murakami H, Fu L, Salomon DS, Seno M
    • Organizer
      AACR Annual meeting 2014
    • Place of Presentation
      アメリカ サンディエゴ
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived exosomes/microvesicles2014

    • Author(s)
      Yan T, Masuda J, Mizutani A, Chen L, Shigehiro T, Matsuda S, Kasai T, Kudoh T, Murakami H, Hendrix MJ, Strizzi L, Salomon DS, Seno M
    • Organizer
      AACR Annual meeting 2014
    • Place of Presentation
      アメリカ サンディエゴ
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cancer stem cells maintain a hierarchy of differentiation by creating their niche2014

    • Author(s)
      Matsuda S, Ting Y, Mizutani A, Murakami H, Seno M
    • Organizer
      第7回高度医療都市を創出する未来科学技術国際シンポジウム
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] In vitro niche created by cancer stem-like cells derived from mouse induced pluripotent stem cell2013

    • Author(s)
      Mizutani A, Matsuda S, Ting Y, Sota T, Kasai T, Murakami H, Kudou T, Seno M
    • Organizer
      American Association for Cancer Research Anuual Meeting 2013
    • Place of Presentation
      アメリカ ワシントンDC
    • Related Report
      2013 Research-status Report
  • [Presentation] Characterization of cancer stem-like cell converted from mouse iPS cell by tumor derived exosome/microvesicle2013

    • Author(s)
      Ting Y, Mizutani A, Chen L, Hiramoto Y, Takaki M, Murakami H, Seno M
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Characterization of cancer stem-like cell converted from mouse iPS cell by tumor derived exosome/microvesicle2013

    • Author(s)
      Ting Y, 水谷昭文、村上宏、妹尾昌治
    • Organizer
      第17回生体触媒化学シンポジウム
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] An insight into cancer stem cells through a cancer stem cell model developed from mouse iPSCs2013

    • Author(s)
      M. Seno, L. Chen, T. Kudoh, T. Kasai, H. Murakami, A. Mizutani
    • Organizer
      19th Internatinal Charles Heidelberger SYmposiumu on Cancer Research
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] miPS-CSC maintains self-renewal and differentiation capacity in vitro by creating a niche2013

    • Author(s)
      T. Yan, S. Matsuda, A. Mizutani, H. Murakami, M. Seno
    • Organizer
      The 6th International symposium for future technology creating better human health and society
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス人工多能性幹細胞より誘導したがん幹細胞モデルの生体外解析2012

    • Author(s)
      松田修一、水谷昭文、笠井智成、佐藤あやの、工藤孝幸、陳凌、妹尾昌治
    • Organizer
      日本癌学会 第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Cancer stem-like cells derived from mouse induced pluripotent stem cell create a niche to promote self-renewal by themselves2012

    • Author(s)
      T.Yan, S.Matsuda, M.Prieto Vila, A.Mizutani, H.Murakami, M.Seno
    • Organizer
      日本分子生物学会 第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] がん幹細胞及びその用途2014

    • Inventor(s)
      妹尾昌治、水谷昭文、笠井智成
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-014778
    • Filing Date
      2014-01-29
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] がん幹細胞を含む細胞集団を得る方法2014

    • Inventor(s)
      妹尾昌治、水谷昭文、笠井智成
    • Industrial Property Rights Holder
      岡山大学、LSIPファンド運営合同会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-03-19
    • Related Report
      2013 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 不均一ながん幹細胞及びその用途2013

    • Inventor(s)
      妹尾昌治、水谷昭文、笠井智成
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-27
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] CANCER CELLS AND APPLICATION THEREOF2013

    • Inventor(s)
      Masaharu Seno
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-19
    • Related Report
      2012 Research-status Report
    • Overseas

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Published: 2013-05-31   Modified: 2019-07-29  

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