Generation of cancer stem cell library from iPS cells for development of drug screening system
| Project/Area Number |
24501315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SENO Masaharu 岡山大学, 大学院自然科学研究科, 教授 (90243493)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | がん幹細胞 / 薬剤スクリーニング / iPS / ドラッグデリバリー / がん幹細胞ニッチ / エクソソーム / 標的化薬剤 / スクリーニング / アポトーシス / iPS細胞 / 脂肪肉腫 / ニッチ |
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| Outline of Final Research Achievements |
In the study of cancer and development of new anticancer drug, cancer stem cells (CSCs) are now considered to be important targets. In this study, we developed a drug screening system using various mouse iPS-derived cancer stem model cells (miPS-CSCs). In addition, we analyzed the gene expression profiles of miPS-CSCs, which focus on cell surface protein to use targeted drug delivery system. Comparison with normal tissue distribution, we nominated several candidate genes for tissue specific targeting.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles2014
Author(s)
Yan T, Mizutani A, Chen L, Takaki M, Hiramoto Y, Matsuda S, Shigehiro T, Kasai T, Kudoh T, Murakami H, Masuda J, Hendrix MJ, Strizzi L, Salomon DS, Fu L, Seno M.
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Journal Title
Journal of Cancer
Volume: 5
Issue: 7
Pages: 572-584
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cancer stem cells maintain a hierarchy of differentiation by creating their niche.2013
Author(s)
Matsuda S, Yan T, Mizutani A, Sota T, Hiramoto Y, Prieto-Vila M, Chen L, Satoh A, Kudoh T, Kasai T, Murakami H, Fu L, Salomon DS, Seno M
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Journal Title
Int J Cancer
Volume: 00
Issue: 1
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Cancer stem cells maintain a hierarchy of differentiation by creating their niche2014
Author(s)
Mizutani A, Matsuda S, Yan T, Prieto-Vila M, Chen L, Satoh A, Kasai T, Masuda J, Kudoh T, Murakami H, Fu L, Salomon DS, Seno M
Organizer
AACR Annual meeting 2014
Place of Presentation
アメリカ サンディエゴ
Year and Date
2014-04-05 – 2014-04-09
Related Report
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[Presentation] Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived exosomes/microvesicles2014
Author(s)
Yan T, Masuda J, Mizutani A, Chen L, Shigehiro T, Matsuda S, Kasai T, Kudoh T, Murakami H, Hendrix MJ, Strizzi L, Salomon DS, Seno M
Organizer
AACR Annual meeting 2014
Place of Presentation
アメリカ サンディエゴ
Year and Date
2014-04-05 – 2014-04-09
Related Report
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