Toll-like receptor-mediated hepatic premetastatic microenvironment
| Project/Area Number |
24501321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
DEGUCHI Atsuko 東京女子医科大学, 医学部, 助教 (10422932)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 大腸がん / 肝転移 / 微小環境 / 大腸癌 / 自然炎症 |
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| Outline of Final Research Achievements |
Primary tumor developed a pre-metastatic niche in distant organs such as liver, lung, or lymph node. In the case of colorectal cancer, liver is one of favorable organs for distant metastasis. To identify molecules that play an important role in development of hepatic premetastatic niche, we performed microarray analysis using RNA obtained from liver at premetastatic phase. Among these up-regulated genes, we have focused on a chemokine-like protein as a candidate for the establishment of premetastatic niche. We suggest that the molecule can function as a TLR ligand, and it plays a crucial role in the establishment of premetastatic niche in liver.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Drug targeting based on a new concept-----Targeting against TLR4 as an example.2015
Author(s)
Maru, Y, Tomita, T, Deguch,i A, Ieguchi, K, Takita, M, Tsukahara, F, Takemura, K, Kitao, A, Gusovsksy, F.
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Journal Title
Endocrine Metabolic and Immune Disorders-Drug Targets
Volume: 2
Related Report
Peer Reviewed
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