| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Primary tumor developed a pre-metastatic niche in distant organs such as liver, lung, or lymph node. In the case of colorectal cancer, liver is one of favorable organs for distant metastasis. To identify molecules that play an important role in development of hepatic premetastatic niche, we performed microarray analysis using RNA obtained from liver at premetastatic phase. Among these up-regulated genes, we have focused on a chemokine-like protein as a candidate for the establishment of premetastatic niche. We suggest that the molecule can function as a TLR ligand, and it plays a crucial role in the establishment of premetastatic niche in liver.
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