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Roles for pyruvate kinase M in tumorigenesis

Research Project

Project/Area Number 24501326
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

TANUMA NOBUHIRO  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Yoji  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (30420045)
ITO Shigemi  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsPKM / 代謝 / ワールブルグ効果 / スプライシング / がん
Outline of Final Research Achievements

Two isoforms of pyruvate kinase M (Pkm), Pkm1 and Pkm2, differentially control flux of carbon sources from glycolysis to TCA cycle. Thus the abundance of Pkm1 and Pkm2 within cells is important to tune a balance between glycolysis and aerobic metabolism. Using primary cells of the mice which are genetically engineered to express only a single isoform of each Pkm, it was revealed that both Pkm1- and Pkm2-driven metabolism play unique and essential roles in cell-fate decisions during cellular senescence and immortalization/trans-formation processes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (17 results) (of which Invited: 5 results)

  • [Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA2015

    • Author(s)
      Hayashi K、ほか20名
    • Journal Title

      Oncogene

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.2015

    • Author(s)
      Hamabe A、ほか13名
    • Journal Title

      Neuro Oncol

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrom2014

    • Author(s)
      Ito S、ほか5名
    • Journal Title

      Pathol Int.

      Volume: 64 Pages: 283-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas.2012

    • Author(s)
      Shibahara I、ほか10名
    • Journal Title

      Int J Clin Oncol

      Volume: 17 Issue: 6 Pages: 551-61

    • DOI

      10.1007/s10147-011-0323-2

    • Related Report
      2014 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas2012

    • Author(s)
      Nomura M、ほか10名
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 931-936

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012

    • Author(s)
      田沼延公
    • Journal Title

      実験医学 特集「がんと代謝」

      Volume: 30 Pages: 42-47

    • Related Report
      2012 Research-status Report
  • [Journal Article] Case report of Mammary Analog Secretory Carcinoma of the parotid gland.2012

    • Author(s)
      Ito S、ほか5名
    • Journal Title

      Pathol Int.

      Volume: 62 Pages: 149-52

    • NAID

      10031185181

    • Related Report
      2012 Research-status Report
  • [Presentation] Regulation of isoform-expression of pyruvate kinase M (PKM) during cellular differentiation and senescence2014

    • Author(s)
      Nomura M、ほか8名
    • Organizer
      第37回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterization of mice expressing a single isoform of pyruvate kinase M2014

    • Author(s)
      Sakamoto Y、ほか8名
    • Organizer
      第73回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単一のピルビン酸キナーゼMアイソフォームを発現するマウスの解析2014

    • Author(s)
      坂本良美、ほか3名
    • Organizer
      第2回 がんと代謝研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発がんに伴う、Pyruvate Kinase Mのアイソザイム変換-代謝再プログラム化における意義解明のための新規マウスモデル2014

    • Author(s)
      坂本良美、野村美有樹、松本祥子、盛田麻美、田中遼太、島礼、渡邊利雄、田沼延公
    • Organizer
      第6回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      三重
    • Related Report
      2013 Research-status Report
  • [Presentation] 「がんの代謝とピルビン酸キナーゼM-ノックインモデルを用いた解析」2013

    • Author(s)
      田沼延公
    • Organizer
      第15回がん・エピゲノム研究会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] PKMアイソフォームに関する生理的、および病態生理的機能解析2013

    • Author(s)
      坂本良美、松本祥子、渡邊利雄、近藤玄、野村美有樹、野村栄樹、椎葉健一、島礼、田沼延公
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 「がんの代謝とピルビン酸キナーゼMによる制御機構」2013

    • Author(s)
      田沼延公
    • Organizer
      第6回Symphony
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Functions of pyruvate kinase M(PKM)isoforms in tumor development2013

    • Author(s)
      Nobuhiro Tanuma
    • Organizer
      第72回日本癌学会学術集会 Symposia"Cancer Cell Metabolism"
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Pyruvate kinase type M2(PKM2)is involved in human gastric cancer development.2013

    • Author(s)
      Takeharu Shiroki,Nobuhiro Tanuma,Ikuro Sato,Nobuyuki Tanaka,Kazuo Sugamura,Kennichi Satoh
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM(PKM)アイソフォームの機能解析2013

    • Author(s)
      坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ピルビン酸キナーゼMと、がんの代謝2013

    • Author(s)
      田沼延公
    • Organizer
      第1回 がんと代謝研究会
    • Place of Presentation
      鶴岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Roles for pyruvate kinase M (PKM) isoforms in tumor metabolism2013

    • Author(s)
      Nobuhiro Tanuma
    • Organizer
      第36回 日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] The pyruvate kinase type M2 (PKM2) expression is enhanced and induces cellular proliferation in human pancreatic cancer cells2013

    • Author(s)
      横山美沙、渋谷利恵、白木健悠、田沼延公、玉井恵一、山口壹範、田中伸幸、菅村和夫、佐藤賢一
    • Organizer
      第36回分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013

    • Author(s)
      松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
    • Organizer
      第36回分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] PKMスイッチ不可能なマウスモデルの開発2013

    • Author(s)
      田沼延公
    • Organizer
      日本癌学会 がん代謝シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] A mouse model incapable of switching PKM isoforms2012

    • Author(s)
      Tanuma N、ほか3名
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] ピルビン酸キナーゼM(PKM)の発現アイソフォームを固定したマウス・細胞モデル2012

    • Author(s)
      田沼延公、ほか10名
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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