| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Two isoforms of pyruvate kinase M (Pkm), Pkm1 and Pkm2, differentially control flux of carbon sources from glycolysis to TCA cycle. Thus the abundance of Pkm1 and Pkm2 within cells is important to tune a balance between glycolysis and aerobic metabolism. Using primary cells of the mice which are genetically engineered to express only a single isoform of each Pkm, it was revealed that both Pkm1- and Pkm2-driven metabolism play unique and essential roles in cell-fate decisions during cellular senescence and immortalization/trans-formation processes.
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