Roles for pyruvate kinase M in tumorigenesis
| Project/Area Number |
24501326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
TANUMA NOBUHIRO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Yoji 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (30420045)
ITO Shigemi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | PKM / 代謝 / ワールブルグ効果 / スプライシング / がん |
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| Outline of Final Research Achievements |
Two isoforms of pyruvate kinase M (Pkm), Pkm1 and Pkm2, differentially control flux of carbon sources from glycolysis to TCA cycle. Thus the abundance of Pkm1 and Pkm2 within cells is important to tune a balance between glycolysis and aerobic metabolism. Using primary cells of the mice which are genetically engineered to express only a single isoform of each Pkm, it was revealed that both Pkm1- and Pkm2-driven metabolism play unique and essential roles in cell-fate decisions during cellular senescence and immortalization/trans-formation processes.
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Report
(4 results)
Research Products
(24 results)
