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Reverse Translational Research for Understanding immune response in the Tumor and Identification of Biomarkers

Research Project

Project/Area Number 24501329
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor immunology
Research InstitutionThe University of Tokyo

Principal Investigator

KAKIMI KAZUHIRO  東京大学, 医学部附属病院, 特任教授 (80273358)

Co-Investigator(Kenkyū-buntansha) UEHA Satoshi  東京大学, 医学(系)研究科, 講師 (00447385)
MATSUSHITA Hirokazu  東京大学, 医学部附属病院, 特任講師 (80597782)
阿部 淳  東京大学, 医学(系)研究科(研究院), 助教 (50581831)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsCTL / 免疫抑制 / PD-1 / γδ T細胞 / 抗腫瘍免疫応答 / がん免疫 / 樹状細胞 / γδT細胞 / MDSC / スニチニブ / IFN-γ / 細胞周期 / 胃がん / 癌性腹膜炎 / 細胞傷害性T細胞 / 骨髄性抑制細胞 / DC / 免疫治療
Outline of Final Research Achievements

To develop novel effective cancer immunotherapy, we performed‘Reverse TR’ study using clinical samples and information from patients who received cancer immunotherapy at the University of Tokyo Hospital. To identify the biomarkers that can help us select patients who are expected to have benefit from immunotherapy, we integrate clinical study and basic immunological study. Many clinical samples were collected by NY-ESO-1 peptide or dendritic cell vaccines and γδ T cell transfer therapy. While some good clinical responses were obtained in certain patients, others did not show such clinical responses despite the induction of anti-tumor immune response. In murine model, we demonstrated that CTLs produce IFN-γ and mediate anti-tumor activity, but they simultaneously induce counter-regulatory immunosuppressive mechanisms in the tumor. These results suggest that strategies to regulate CTL-induced immunosuppressive microenvironment would improve the efficacy of cancer immunotherapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (45 results)

All 2015 2014 2013 2012

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (28 results) (of which Invited: 8 results)

  • [Journal Article] Robust anti-tumor effects of combined anti-CD4 depleting antibody and anti-PD-1/PD-L1immune checkpoint antibody treatment in mice.2015

    • Author(s)
      Ueha S, Yokochi S, Ishiwata Y, Ogiwara H, Chand K, Nakajima T, Hachiga K,Shichino S, Terashima Y, Toda E, Shand FH, Kakimi K, Ito S, Matshushima K.
    • Journal Title

      Cancer Immunol Res.

      Volume: Epub ahead of print Issue: 6 Pages: 631-640

    • DOI

      10.1158/2326-6066.cir-14-0190

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFN-γ-dependent cell cycle arrest.2015

    • Author(s)
      Matsushita H, Hosoi A, Ueha S, Abe J, Fujieda N, Tomura M, Maekawa R, Matsushima K, Ohara O, Kakimi K.
    • Journal Title

      Cancer Immunol Res.

      Volume: 3 Issue: 1 Pages: 26-36

    • DOI

      10.1158/2326-6066.cir-14-0098

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] γδ T cell therapy for the treatment of non-small cell lung cancer.2014

    • Author(s)
      Kakimi K, Matsushita H, Murakawa T, Nakajima J.
    • Journal Title

      Transl Lung Cancer Res

      Volume: 3 Pages: 23-33

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A pilot study of autologous tumor lysate-loaded dendritic cell vaccination combined with sunitinib for metastatic renal cell carcinoma2014

    • Author(s)
      Matsushita H, Enomoto Y, Kume H, Nakagawa T, Fukuhara H, Suzuki M, Fujimura T, Homma Y, Kakimi K.
    • Journal Title

      J Immunother Cancer.

      Volume: 2 Issue: 1 Pages: 30-30

    • DOI

      10.1186/s40425-014-0030-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antitumor immunity by magnetic nanoparticle-mediated hyperthermia.2014

    • Author(s)
      Kobayashi T, Kakimi K, Nakayama E, Jimbow K.
    • Journal Title

      Nanomedicine (Lond)

      Volume: 9 Issue: 11 Pages: 1715-26

    • DOI

      10.2217/nnm.14.106

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulocyte macrophage colony-stimulating factor as a predictor of the response of metastatic renal cell carcinoma to tyrosine kinase inhibitor therapy.2014

    • Author(s)
      Yamada D, Matsushita H, Azuma T, Nakagawa T, Nagata M, Yamada Y, Suzuki M, Fujimura T, Fukuhara H, Kume H, Homma Y, Kakimi K.
    • Journal Title

      Mol Clin Oncol

      Volume: 2 Issue: 6 Pages: 1023-27

    • DOI

      10.3892/mco.2014.360

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High expression of heat shock protein 105 predicts a favorable prognosis for patients with urinary bladder cancer treated with radical cystectomy.2014

    • Author(s)
      Kawai T, Enomoto Y, Morikawa T, Matsushita H, Kume H, Fukayama M, Yamaguchi H, Kakimi K, Homma Y.
    • Journal Title

      Mol Clin Oncol

      Volume: 2 Issue: 1 Pages: 38-42

    • DOI

      10.3892/mco.2013.203

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer.2014

    • Author(s)
      Wada I, Matsushita H, Noji S, Mori K, Yamashita H, Nomura S, Shimizu N, Seto Y, Kakimi K
    • Journal Title

      Cancer Med

      Volume: 3 Issue: 2 Pages: 362-375

    • DOI

      10.1002/cam4.196

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vaccination With NY-ESO-1 Overlapping Peptides Mixed With Picibanil OK-432 and Montanide ISA-51 in Patients With Cancers Expressing the NY-ESO-1 Antigen2014

    • Author(s)
      Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Yamasaki M, Miyata H, Matsushita H, Udono H, Seto Y, Yamada K, Nishikawa H, Pan L, Venhaus R, Oka M, Doki Y, Nakayama E.
    • Journal Title

      J Immunother

      Volume: 37(2) Issue: 2 Pages: 84-92

    • DOI

      10.1097/cji.0000000000000017

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of CD204-positive macrophages in upper urinary tract cancer2014

    • Author(s)
      Ichimura T, Morikawa T, Kawai T, Nakagawa T, Matsushita H, Kakimi K, Kume H, Ishikawa S, Homma Y, Fukayama M.
    • Journal Title

      Ann Surg Oncol.

      Volume: 21 Issue: 6 Pages: 2105

    • DOI

      10.1245/s10434-014-3503-2

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adoptive cytotoxic T lymphocyte therapy triggers a counter-regulatory immunosuppressive mechanism via recruitment of myeloid-derived suppressor cells.2014

    • Author(s)
      Hosoi A, Matsushita H, Shimizu K, Fujii SI, Ueha S, Abe J, Kurachi M, Maekawa R, Matsushima K, Kakimi K.
    • Journal Title

      Int J Cancer.

      Volume: 134 Issue: 8 Pages: 1810-22

    • DOI

      10.1002/ijc.28506

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of NY-ESO-1 peptide/DRB1*08:03 tetramers and ex vivo detection of CD4 T-cell responses in vaccinated cancer patients.2014

    • Author(s)
      Mizote Y, Uenaka A, Isobe M, Wada H, Kakimi K, Saika T, Kita S, Koide Y, Oka M, Nakayama E.
    • Journal Title

      Vaccine.

      Volume: Epub 2014 Jan 5. Issue: 8 Pages: 957-964

    • DOI

      10.1016/j.vaccine.2013.12.042

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain andthe common γ-chain.2013

    • Author(s)
      Izumi T, Kondo M, Takahashi T, Fujieda N, Kondo A, Tamura N, Murakawa T, Nakajima J, Matsushita H, Kakimi K.
    • Journal Title

      Cytotherapy

      Volume: 15(4) Issue: 4 Pages: 481-491

    • DOI

      10.1016/j.jcyt.2012.12.004

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells.2013

    • Author(s)
      Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S.
    • Journal Title

      Cancer Res.

      Volume: 73(1) Issue: 1 Pages: 62-73

    • DOI

      10.1158/0008-5472.can-12-0759

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.2013

    • Author(s)
      Eikawa, S., Kakimi, K., Idobe, M., Kuzushima, K., Luescher, I., Ohue, Y., Ikeuchi, K., Uenaka, A., Nishikawa, H., Udono, H., Oka, M., and Nakayama, E.
    • Journal Title

      Int. J. Cancer

      Volume: 132(2) Issue: 2 Pages: 345-54

    • DOI

      10.1002/ijc.27682

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] HSP70 and HSP90 differentially regulate translocation of extracellular antigen to the cytosol for cross-presentation.2012

    • Author(s)
      Kato Y, KajiwaraC, IshigeI, MizukamiS, YamazakiC, EikawaS, KakimiK. and Udono H.
    • Journal Title

      Autoimmune diseases

      Volume: Volume 2012 Pages: 10-10

    • DOI

      10.1155/2012/745962

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeting spatiotemporal expression of CD137 on tumor-infiltrating cytotoxic T lymphocytes as a novel strategy for agonistic antibody therapy.2012

    • Author(s)
      Noji S, Hosoi A, Takeda K, Matsushita H, Morishita Y, Seto Y, Kakimi K.
    • Journal Title

      J. Immunother

      Volume: 35(6) Issue: 6 Pages: 460-472

    • DOI

      10.1097/cji.0b013e31826092db

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] CTL治療における腫瘍内免疫応答の解析2015

    • Author(s)
      垣見和宏
    • Organizer
      第12回日本免疫治療学研究会学術集会
    • Place of Presentation
      東京ガーデンパレス(東京都文京区)
    • Year and Date
      2015-02-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NY-ESO-1 ペプチドワクチンによって誘導されたCTLモニタリングのためのTCRディープシーケンス2015

    • Author(s)
      宮井まなみ、細井亮宏、松下博和、榮川伸吾、磯辺みどり、上中明子、鵜殿平一郎、中山睿一、垣見和宏
    • Organizer
      第12回日本免疫治療学研究会学術集会
    • Place of Presentation
      東京ガーデンパレス(東京都文京区)
    • Year and Date
      2015-02-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Autologous tumor lysate-loaded dendritic cell vaccination combined with Sunitinib for metastatic renal cell carcinoma2014

    • Author(s)
      Kazuhiro Kakimi, Hirokazu Matsushita, Yutaka Enomoto, Tohru Nakagawa, Haruki Kume and Yukio Honma
    • Organizer
      SITC (Society for immunotherapy of Cancer) 2014
    • Place of Presentation
      Gaylord National Hotel & Convention Center, National Harbor, MD, USA
    • Year and Date
      2014-11-07 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食道がんに対するDCF療法と活性化自己γδT細胞治療の併用による治療効果の検討2014

    • Author(s)
      森和彦、松下博和、平野康介、山田和彦、山下裕玄、野村幸代、瀬戸泰之、垣見和宏
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-08-09 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腫瘍内の免疫抑制性環境の制御による腫瘍特異的CTL移入治療の増強2014

    • Author(s)
      細井亮宏、平野康介、松下博和、瀬戸泰之、前川隆司、垣見和宏
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-31 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] γδT細胞を用いたがん免疫細胞治療におけるTIM-3とGalectin-9の相互作用2014

    • Author(s)
      神原佳織、藤枝奈緒、大平公亮、近藤篤、近藤真、泉謙道、高橋卓也、松下博和、和田郁雄、瀬戸泰之、垣見和宏
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      発表場所ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] TCRディープシーケンスによるNY-ESO-1特異的T細胞のモニタリング2014

    • Author(s)
      垣見和宏、榮川伸吾、磯辺みどり、松下博和、宮井まなみ、細井亮宏、藤枝奈緒、鵜殿平一郎、上中明子、中山睿一
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 制御性T細胞解析方法の標準化に向けた多施設共同研究2014

    • Author(s)
      長瀬博次、和田尚、西川博嘉、鈴木進、平家勇司、小島隆嗣、垣見和宏、舩越建、飯田真介、石田高司、佐藤永一、鵜殿平一郎、岡美喜男、中山睿一、土岐一郎、上田龍三
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of γδ T cell-based cancer immunotherapy2014

    • Author(s)
      垣見和宏
    • Organizer
      第18回日本がん免疫学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CTL therapy-induced immunosuppressive microenvironment in the tumor is potentiated by the recruitment of MDSCs.2014

    • Author(s)
      Akihiro Hosoi, Hirokazu Matsushita, Satoshi Ueha, Kouji Matsushima and Kazuhiro Kakimi.
    • Organizer
      MMCB 2014, The 22nd International Symposium on Molecular Cell Biology of Macrophages.
    • Place of Presentation
      The Kobe Chamber of Commerce and Industry (Kobe CCI), Kobe, Japan
    • Year and Date
      2014-07-02 – 2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん免疫治療新時代に向けて2014

    • Author(s)
      垣見和宏
    • Organizer
      平成26年度沖縄県委託事業「先端医療産業開発拠点形成事業」
    • Place of Presentation
      琉球大学(沖縄県中頭郡西原町)
    • Year and Date
      2014-05-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Killing and IFN-γ-dependent G1 cell cycle arrest is the mechanism of regulation of tumor growth by Cytotoxic T Lymphocytes.2013

    • Author(s)
      Kazuhiro Kakimi, Hirokazu Matsushita, Akihiro Hosoi, Ryuji Maekawa, and Osamu Ohara.
    • Organizer
      AACR Annual Meeting 2013,
    • Place of Presentation
      Washington DC, USA (The Walter E. Washington Convention Center )
    • Related Report
      2013 Research-status Report
  • [Presentation] Killing and IFN-γ-dependent G1 cell cycle arrest is the mechanism of regulation of tumor growth by Cytotoxic T Lymphocytes.2013

    • Author(s)
      Hirokazu Matsushita, Akihiro Hosoi, Satoshi Ueha, Jun Abe, Michio Tomura, Ryuji Maekawa, Osamu Ohara, Kazuhiro Kakimi.
    • Organizer
      21st Annual cancer research Institute International cancer
    • Place of Presentation
      NY, USA (The Grand Hyatt in New York City)
    • Related Report
      2013 Research-status Report
  • [Presentation] 癌免疫治療新時代に向けて2013

    • Author(s)
      垣見和宏
    • Organizer
      第34回癌免疫外科研究会
    • Place of Presentation
      岡山県、岡山市(岡山プラザホテル)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] クリニカルゲノミクスへの期待:がん免疫治療の見地から2013

    • Author(s)
      垣見和宏
    • Organizer
      かずさDNA 研究所/産総研 生命情報工学研究センター共催ワークショップ
    • Place of Presentation
      東京都(産総研臨海副都心センター別館)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ヒトがん免疫病態の解明と免疫バイオマーカーの同定2013

    • Author(s)
      河上裕、徐明利、谷口智憲、野地しのぶ、南雲春菜、岡本正人、桜井敏晴、藤田知信、鳥越俊彦、佐藤昇志、中面哲也、垣見和宏、池田裕明、珠玖洋、奥野清隆、杉浦史哲、中山睿一、硲彰一、岡正朗、伊東恭吾
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      山口県、宇部市(ANAクラウンプラザホテル)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 治療抵抗性胃癌患者の腹膜播種に対するγδT細胞治療2013

    • Author(s)
      近藤篤、和田郁雄、藤枝奈緒、神原佳織、泉謙道、高橋卓也、前川隆司、松下博和、瀬戸泰之、垣見和宏
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      山口県、宇部市(ANAクラウンプラザホテル)
    • Related Report
      2013 Research-status Report
  • [Presentation] Vγ9Vδ2 T cells are a promising target of a chimeric antigen receptor gene transfer for adoptive immunotherapy2013

    • Author(s)
      Yuta Inoue, Jun Nakajima, Tomohiro Murakawa, Hirokazu Matsushita, Kazuhiro Kakimi.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市(パシフィコ横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] Autologous γδT Cell Transfer Therapy for The Treatment of Cancer2013

    • Author(s)
      Kazuhiro Kakimi
    • Organizer
      第42回日本免疫学会総会/学術集会
    • Place of Presentation
      千葉県千葉市(幕張メッセ)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Adoptive cytotoxic T lymphocyte therapy triggers a counterregulatory immunosuppressive mechanism via recruitment of myeloid-derived suppressor cells2013

    • Author(s)
      Hosoi Akihiro, Matsushita Hirokazu, Shimizu Kanako, Fujii Shin-ichiro, Ueha Satoshi, Abe Jun, Maekawa Ryuji, Matsushima Kouji, Kakimi Kazuhiro
    • Organizer
      第42回日本免疫学会総会/学術集会
    • Place of Presentation
      千葉県千葉市(幕張メッセ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Autologous γδT cell transfer therapy for the treatment of Solid Cancer2013

    • Author(s)
      Kazuhiro Kakimi
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      Vancouver, British Columbia, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] High expression of Heat Shock Protein 105 Predicts Favorable Prognosis in Bladder Cancer Patients Treated by a Radical Cystectomy2012

    • Author(s)
      Yutaka Enomoto, Haruki Kume, Hiroshi Fukuhara, Tetsuya Fujimura, Motofumi Suzuki, Hiroaki Nishimatsu, Akira Ishikawa, Hirokazu Matsushita, Kazuhiro Kakimi, Yukio Homma.
    • Organizer
      11th Asian Congress of Urology
    • Place of Presentation
      Pattaya, Thailand
    • Related Report
      2012 Research-status Report
  • [Presentation] Dendritic Cell-based Immunotherapy Combined with Sunitinib for Metastatic Renal Cell Carcinoma2012

    • Author(s)
      Yutaka Enomoto, Haruki Kume, Hiroshi Fukuhara, Tetsuya Fujimura, Motofumi Suzuki, Hiroaki Nishimatsu, Akira Ishikawa, Hirokazu Matsushita, Kazuhiro Kakimi, Yukio Homma.
    • Organizer
      The 32nd Congress of the Societe Internationale d’Urokigue,
    • Place of Presentation
      Fukuoka,Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Autologous γδT cell transfer therapy for the treatment of Solid Cancer2012

    • Author(s)
      Kazuhiro Kakimi.
    • Organizer
      The 9th Catholic International Stem Cell Symposium: step up to Translational Research
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] がんと免疫~ワクチン治療と免疫細胞移入治療~2012

    • Author(s)
      垣見和宏
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 腹水貯留を伴う治療抵抗性胃癌患者に対するγδT細胞腹腔内投与治療2012

    • Author(s)
      田村直久、和田郁雄、清水伸幸、野村幸世、近藤篤、藤枝奈緒、近藤真、泉謙道、高橋卓也、前川隆司、松下博和、瀬戸泰之、垣見和宏.
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 食道癌に対するγδT細胞移入療法の治療効果検討2012

    • Author(s)
      藤枝奈緒、野地秀一、森和彦、近藤篤、田村直久、近藤真、泉謙道、高橋卓也、前川隆司、松下博和、瀬戸泰之、垣見和宏
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] CTL therapy regulates tumor growth by IFN-g-dependent cell cycle arrest2012

    • Author(s)
      Matsuhsia Hirokazu, Hosoi Akihiro, Ueha Satoshi, Abe Jun, Tomura Michio, Maekawa Ryuji, Ohara Osamu, Kakimi Kazuhiro
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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