Development of MIF vaccine therapy against inflammation-related colon carcinogenesis
| Project/Area Number |
24501332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Hokkai-Gakuen University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takuma 三重大学, 大学院医学系研究科, 准教授 (60224515)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ワクチン療法 / 抗自己サイトカイン / IBD / MIF / 発がん / DNAワクチン |
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| Outline of Final Research Achievements |
MIF DNA vaccine shows a preventive and therapeutic effect in a number of models of inflammations, including enteritis. For induction of anti-MIF auto-antibody, the vaccine incorporates a helper T epitope, a peptide fragment (TTX) from the tetanus toxin. In the present study, a new series of MIF vaccine were prepared that employed epitopes from ovalbumin (OVA), egg white lysozyme (HEL), and tetanus toxin (TET830). On the other hand, it has been confirmed that, in inflammation-induced colon cancer model, the expression of various cytokines (IL-4, IL-17a, GM-CSF), chemokines (CCL12, CCL20) and MMP3 is concord with that of MIF. Upon inoculation with the initial type MIF-DNA vaccine, carcinogenesis inhibitory effect could be confirmed with good reproducibility.
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation.2014
Author(s)
Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H, Katayama N, Kato T.
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Journal Title
PLOS ONE
Volume: 9
Issue: 9
Pages: e108494-e108494
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8(+) T cells.2013
Author(s)
Muraoka, D., Nishikawa, H., Noguchi, T., Wang, L., Harada, N., Sato, E., Luescher, I., Nakayama, E., Kato, T., Shiku, H.
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Journal Title
Vaccine
Volume: 31
Pages: 2110-8
Related Report
Peer Reviewed
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[Journal Article] Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes.2013
Author(s)
Hirayama, M., Nishikawa, H., Nagata, Y., Tsuji, T., Kato, T., Kageyama, S., Ueda, S., Sugiyama, D., Hori, S., Sakaguchi, S., Ritter, G., Old, L. J., Gnjatic, S., Shiku, H.
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Journal Title
European Journal of Immunology
Volume: 43
Pages: 989-1000
Related Report
Peer Reviewed
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[Presentation] Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation.2015
Author(s)
Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H, Katayama N, Kato T.
Organizer
World Immune Regulation Meeting IX
Place of Presentation
Davos, Switzerland
Year and Date
2015-03-18 – 2015-03-21
Related Report
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