Synergistic enhancement of tumor vaccine efficacy mediated by herbal medicines
| Project/Area Number |
24501335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TAKAKU SHUN 日本医科大学, 医学部, 講師 (50445813)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 漢方薬 / アジュバント / ワクチン / 腫瘍免疫 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the anti-tumor effect by an oral administration of a Japanese herbal medicine, Ninjin-Yoei-To (NYT), in conjunction with or without an irradiated tumor cell vaccine. When mice were fed with control diet, the irradiated tumor cell vaccine in prophylactic setting somewhat delayed tumor growth, although NYT-mixed diet alone did not show any anti-tumor effect. Nonetheless, tumor growth was significantly inhibited in vaccinated mice treated with NYT and depletion of CD8+ T cells completely abrogated the tumor vaccine efficacy. The anti-tumor immunity was augmented only when vaccinated mice were fed with NYT throughout the experiments, but neither before nor after tumor challenge. Taken together, these data indicated that NYT feeding synergistically enhances prophylactic vaccine efficacy mediated by CD8+ T cells and that such Japanese herbal medicines may be useful as excellent adjuvants for cancer immunotherapy.
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Report
(4 results)
Research Products
(9 results)
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[Presentation] IL-15 enhances CD8+ HIV-1 gp160-specific murine CTL resistance to both Fas-FasL and perforin-granzyme mediated apoptosis induced by free antigenic peptide2014
Author(s)
Takaku, S., Nakagawa, Y., Murakami, R., Shimizu, M., Owaki, A., Takahashi, H
Organizer
第43回日本免疫学会学術集会
Place of Presentation
京都国際会議場
Year and Date
2014-12-10 – 2014-12-12
Related Report
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[Presentation] Inactivation of tumor-specific CD8+ CTLs by tumor infiltrating tolerogenic dendritic cells expressing down-modulated costimulating molecules.2013
Author(s)
Harimoto, H., Shimizu, M., Nakagawa, Y., Takaku, S., Wakabayashi, A., Takahashi H
Organizer
第42回日本免疫学会学術集会
Place of Presentation
幕張メッセ
Related Report
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[Presentation] Manipulation of rapid apoptosis for HIV-1 gp160-specific murine CD8+ CTLs by free antigenic peptide in vivo2013
Author(s)
Takahashi H. Shimizu, M., Norose, Y., Takaku, S., Takahashi, M., Nakagawa, Y
Organizer
15th International Congress of Immunology
Place of Presentation
Milan, Italy
Related Report
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[Presentation] Induction of apoptosis-resistant and TGF-b-insensitive murine CD8+ cytotoxic T lymphocytes specific for HIV-1 gp1602012
Author(s)
Takaku, S., Nakagawa, Y., Owaki, A., Shimizu, M., Takahashi, M., Takahashi, H
Organizer
第41回日本免疫学会総会
Place of Presentation
神戸国際会議場
Related Report
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