• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of new biomarkers and therapeutic targets for lung cancer

Research Project

Project/Area Number 24501341
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor diagnosis
Research InstitutionThe University of Tokyo (2014)
Shiga University of Medical Science (2012-2013)

Principal Investigator

ATSUSHI TAKANO  東京大学, 医科学研究所, 特任講師 (50582607)

Co-Investigator(Kenkyū-buntansha) DAIGO Yataro  滋賀医科大学, 医学部, 教授 (30325029)
醍醐 弥太郎  滋賀医科大学, 医学部, 教授 (30345029)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバイオマーカー / 治療標的分子 / 国際情報交換 / アメリカ
Outline of Final Research Achievements

We identified a secreted proteins, LASEP1 and LASEP3 (LASEPs) as a candidate. Immunohistochemical staining showed that high level of LASEPs expression was associated with poor prognosis for NSCLC patients. Serum LASEPs levels were higher in NSCLC patients than in healthy volunteers. Furthermore, reduction of LASEPs by siRNA suppressed lung cancer cell proliferation and induced apoptosis. In addition, subsequent microarray analysis of these cancer cells identified several candidate downstream genes of LASEPs that relate to cell growth signals.
Next generation sequencer analysis detected tumor-specific mutation in lung cancer tissue. In addition, we detected mutation in mRNA from serum exosome or free DNA from serum by digital PCR. Digital PCR analysis showed that activating EGFR mutation in serum exosome was detected 4 cases out of 10.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (18 results)

  • [Journal Article] Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers.2014

    • Author(s)
      Kobayashi Y, Takano A, Miyagi Y, Tsuchiya E, Sonoda H, Shimizu T, Okabe H, Tani T, Fujiyama Y, Daigo Y.
    • Journal Title

      International journal of oncology

      Volume: 44 Issue: 1 Pages: 69-77

    • DOI

      10.3892/ijo.2013.2177

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer using Genomic Analyses.2013

    • Author(s)
      Daigo Y, Takano A, Teramoto K, Chung S, Nakamura Y.
    • Journal Title

      Clin Pharmacol Ther

      Volume: 94 Issue: 2 Pages: 218-223

    • DOI

      10.1038/clpt.2013.90

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer.2013

    • Author(s)
      Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
    • Journal Title

      Molecular Cancer Research

      Volume: Epub ahead of print Pages: 0-0

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 肺癌の新規診断マーカー、予後マーカー、治療標的分子であるLASEP1の機能解析2014

    • Author(s)
      高野淳、中村祐輔、醍醐弥太郎
    • Organizer
      第59回人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-19 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterization of LASEP3 as a serum diagnostic and prognostic biomarker and therapeutic target for lung cancer.2014

    • Author(s)
      Takano A, Nakamura Y, Daigo Y.
    • Organizer
      第73回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] LASEP3 as a serological and prognostic biomarker and a therapeutic target2014

    • Author(s)
      Takano A, Nakamura Y, Daigo Y.
    • Organizer
      第12回日本臨床腫瘍学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-07-17 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of a lung cancer growth factor, LASEP1 as a serological and prognostic biomarker and a therapeutic target2014

    • Author(s)
      Takano A, Nakamura Y, Daigo Y.
    • Organizer
      2014 ASCO annual meeting
    • Place of Presentation
      シカゴ、米国
    • Year and Date
      2014-05-30 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characterization of LASEP3 as a serological and prognostic biomarker and a therapeutic target for lung cancer2014

    • Author(s)
      Takano A, Nakamura Y, Daigo Y.
    • Organizer
      2014 AACR annual meeting
    • Place of Presentation
      サンディエゴ、米国
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] トランスクリプト―ム解析により同定した肺癌の新規バイオマーカーで治療標的分子であるLASEP3の機能解析2013

    • Author(s)
      高野淳、中村祐輔、醍醐弥太郎
    • Organizer
      第58回人類遺伝学会大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Characterization of LASEP1 as a serological and prognostic biomarker and a therapeutic target for lung cancer2013

    • Author(s)
      高野淳、中村祐輔、醍醐弥太郎
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Characterization of a lung cancer growth factor, LASEP3 as a serological and prognostic biomarker and therapeutic target2013

    • Author(s)
      高野淳、中村祐輔、醍醐弥太郎
    • Organizer
      第11回臨床腫瘍学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of LASEP3 as a new serological and prognostic biomarker for lung cancer.2013

    • Author(s)
      高野淳、中村祐輔、醍醐弥太郎
    • Organizer
      2011 ASCO Annual meeting
    • Place of Presentation
      Chicago, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 大学病院におけるがん薬物療法レジメン審査委員会が果たす役割と今後の課題2013

    • Author(s)
      高野淳、醍醐弥太郎
    • Organizer
      第110回日本内科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Characterization of a lung cancer growth factor, LASEP3 as a serological and prognostic biomarker and a therapeutic target2013

    • Author(s)
      高野淳、中村祐輔、醍醐弥太郎
    • Organizer
      2013 AACR Annual meeting
    • Place of Presentation
      Wachington, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Characterization of a lung cancer growth factor, LASEP3 as a serological and prognostic biomarker and a therapeutic target2013

    • Author(s)
      高野 淳、中村 祐輔、醍醐 弥太郎
    • Organizer
      AACR annual meeting 2013
    • Place of Presentation
      ワシントンDC、アメリカ合衆国
    • Related Report
      2012 Research-status Report
  • [Presentation] Characterization of a lung cancer growth factor, LASEP1, as a serologic and prognostic biomarker and therapeutic target.2013

    • Author(s)
      高野 淳、中村 祐輔、醍醐 弥太郎
    • Organizer
      ASCO annual meeting 2013
    • Place of Presentation
      シカゴ、アメリカ合衆国
    • Related Report
      2012 Research-status Report
  • [Presentation] 包括的遺伝子解析に基づいた肺癌の新規診断マーカー・治療標的分子であるLASEP1の同定と機能解析2012

    • Author(s)
      高野 淳、中村 祐輔、醍醐 弥太郎
    • Organizer
      第56回人類遺伝学会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2012 Research-status Report
  • [Presentation] Characterization of a lung cancer growth factor, LASEP1 as a serological and prognostic biomarker and a therapeutic target2012

    • Author(s)
      高野 淳、中村 祐輔、醍醐 弥太郎
    • Organizer
      第10回日本臨床腫瘍学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification of LASEP3 as a diagnostic biomarker and therapeutic target for lung cancer2012

    • Author(s)
      高野 淳、中村 祐輔、醍醐 弥太郎
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification and analysis of a lung cancer growth factor, LASEP1 as a serological and prognostic biomarker and a therapeutic target2012

    • Author(s)
      高野 淳、中村 祐輔、醍醐 弥太郎
    • Organizer
      AACR annual meeting 2012
    • Place of Presentation
      シカゴ、アメリカ合衆国
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification of LASEP3 as a new serological and prognostic biomarker for lung and various type of cancer2012

    • Author(s)
      高野 淳、中村 祐輔、醍醐 弥太郎
    • Organizer
      ASCO annual meeting 2012
    • Place of Presentation
      シカゴ、アメリカ合衆国
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi