| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
We revealed that CDK inhibitor induced autophagy in some, but not all, solid cancer cell lines. In the cell lines showing autophagy, which was induced by CDK inhibitor, the combination of CDK inhibitor and autophagy inhibition induced apoptosis. However, it did not induce apoptosis in the cell lines in which autophagy was not induced by CDK inhibitor. These findings indicate that the autophagy induced by CDK inhibitor mimics stress-induced autophagy in some solid cancer cell lines. The combination of a small-molecule CDK inhibitor involved in G1/S arrest and an autophagy inhibitor leads to a synthetic lethal interaction and could become a new antitumor strategy for solid tumors showing cytoprotective autophagy induced by small-molecule CDK inhibitors.
|
